Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1993-06-09
1997-02-25
Harris-Kelly, Cynthia
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 169, 424 177, 534 16, A61K 5100, C07F 500
Patent
active
056056729
ABSTRACT:
The invention features a method of blood pool imaging which utilizes an imaging agent which can be easily labelled with a radioactive isotope and injected into a patient. The imaging agent is a covalent conjugate of a polymeric carrier, protective groups, and chelating groups. The imaging agent is preferably provided in the form of a blood pool imaging composition, which includes an imaging agent of the invention, a buffer and a reducing compound. A radioactive isotope is added to the blood pool imaging composition to label the imaging agent, and the composition containing the labelled imaging agent is injected intravenously into a patient.
REFERENCES:
patent: 4647447 (1987-03-01), Gries et al.
patent: 4707352 (1987-11-01), Staurianopolous
patent: 4849208 (1989-07-01), Stavrianopoulos
patent: 4855353 (1989-08-01), Kurami et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 4951675 (1990-08-01), Groman et al.
patent: 5057313 (1991-10-01), Shih et al.
patent: 5069216 (1991-12-01), Groman et al.
patent: 5094848 (1992-03-01), Brixner
patent: 5141739 (1992-08-01), Jung et al.
patent: 5160725 (1992-11-01), Pilgrimm
patent: 5164176 (1992-11-01), Gustavson et al.
patent: 5171563 (1992-12-01), Abrams et al.
patent: 5208324 (1993-05-01), Klaveness et al.
patent: 5213788 (1993-05-01), Ranney
patent: 5250666 (1993-10-01), Gustavson et al.
patent: 5328992 (1994-07-01), Peter et al.
patent: 5382654 (1995-01-01), Tyle et al.
Sawhney et al., Biomaterials 13(12) 1992, pp. 863-870 as Abstracted in Chemical Abstracts AN 118:11690 See Abstract.
Klibanov et al., Am. J. Physiol, 261 (4, suppl), pp. 60-65 as Abstracted in Chemical Abstracts AN 115:239558, See Abstract.
Pimm et al., EP. Jour. Nuc. Med., Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier, Jun., 1992.
Zanelli, Nuclear Medicine, The Preparation of kits for labelling macromolecules of biological interest with technetium-99m, 1987.
Abuchowski et al., J. Biol. Chem., 252:3578-81 (1977).
Abuchowski et al., Bioch. Biophy. Acta., 578:41-46 (1979).
Abuchowski et al., J. Biol. Chem., 252:3582-86 (1977).
Abuchowski and Davis, "Soluble Polymer-Enzyme Adducts," Ch. 13, Enzymes as Drugs, (Wiley, New York 1981).
Beauchamp et al., Anal. Biochem., 131:25-33 (1983).
Chazov et al., Thromb. Res., 12, 809-816 (1978).
Chung-Ja et al., Anal. Biochem., 165:114-127 (1987).
Duewell et al., Invest. Radiol., 26:50-57 (1991).
Fujimoto et al., Cancer, 56:2404-2410 (1985).
Kennady et al., Am. Surg., 33:763-771 (1967).
Manabe et al., Biochem. Biophys. Acta, 883:460-67 (1986).
Schmiedl, et al., Invest. Radiol., 26:65-70 (1991).
Schumann-Giampieri et al., Invest. Radiol., 26:969-974 (1991).
Torchilin et al., J. Biomed. Mater. Res., 11:223-234 (1977).
Torchilin et al., J. Biom. Mater. Res., 19:461-466 (1985).
Winding, O., Neuroradiol., 21:123-126 (1981).
Wright et al., Radiology, 142:351-54 (1982).
Bogdanov Alexei A.
Brady Thomas J.
Callahan Ronald
Weissleder Ralph
Harris-Kelly Cynthia
The General Hospital Corporation
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