Blood platelet loaded with diagnostic or therapeutic-containing

Details Blood platelet loaded with diagnostic or therapeutic-containing Blood platelet loaded with diagnostic or therapeutic-containing

1991-09-06

1994-03-08

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to or within viable or inviable whole...

424450, 424 4, 424532, A61K 3722, A61K 4300, A61K 4904, A61M 3614

Patent

active

052925242

ABSTRACT:
The invention provides loaded platelets that include an absorbed loading vehicle having associated diagnostic or therapeutic agents. A method of loading platelets with diagnostic or therapeutic agents is provided. The method includes combining a loading vehicle having associated diagnostics or therapeutic agents with platelets at sufficient concentration and temperature to allow uptake of the loading vehicle by the platelets. Also provided is a method of targeting diagnostic or therapeutic agents to platelet localizing areas. The method includes the steps of: (a) combining a loading vehicle having associated diagnostic or therapeutic agents with platelets at sufficient concentration and temperature to allow uptake of the loading vehicle by the platelets; (b) isolating the platelets from excess loading vehicle; and (c) administering the isolated platelets to an animal in an effective concentration so as to promote targeting of the isolated platelets to platelet localizing areas. A method of imaging is also provided.

REFERENCES:
patent: 4938948 (1990-07-01), Ring et al.
patent: 5047245 (1991-09-01), Bally et al.
patent: 5213788 (1993-05-01), Ranney
Male et al (1992) Proc. Natl. Acad. Sci. 89, pp. 9191-9195.
Male et al (1991) Faseb 5, A523.
Doerschuk et al (1989) Thrombosis and Haemostasis 61, pp. 392-396.

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