Blood oxygenating and cerebral vasoregulating 20,21-dinoreburnam

Details Blood oxygenating and cerebral vasoregulating 20,21-dinoreburnam Blood oxygenating and cerebral vasoregulating 20,21-dinoreburnam

1982-09-21

1985-02-26

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 51, A61K 31435, C07D46100

Patent

active

045017409

ABSTRACT:
Novel 20,21-dinoreburnamenines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and .dbd.CH.sub.2, the wavy line connecting to the E ring being a single bond when R is hydrogen or alkyl of 1 to 4 carbon atoms or a double bond when R is .dbd.CH.sub.2 and the dotted line being possibly an endo carbon-carbon bond when R is hydrogen or alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts in all their possible isomers forms, racemic mixtures and optical isomers having oxygenating and cerebral vasoregulating activity of great value and a novel process and intermediates for their preparation.

REFERENCES:
patent: 3830823 (1974-08-01), Castaigne
patent: 3937709 (1976-02-01), Sevenet et al.
patent: 4033969 (1977-07-01), Sevenet et al.
patent: 4120858 (1978-10-01), Clauder et al.
patent: 4163851 (1979-08-01), Clauder et al.
patent: 4291038 (1981-09-01), Farcilli et al.

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