Blood lipid ameliorant composition

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S250000, C514S460000, C514S458000, C514S553000, C514S561000, C514S474000, C514S724000, C536S022100, C536S023100, C435S004000, C435S006120, C424S401000, C424S472000, C424S059000, C424S065000

Reexamination Certificate

active

07012067

ABSTRACT:
A blood lipid ameliorating composition containing simvastatin and one or more ingredients selected from a riboflavin compound, a d-α-tocopherol compound, an ascorbic acid compound, pantethine, and taurine.

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patent: WO 97/38694 (1997-10-01), None
Neuteufl Thomas, “Additional benefit of vitamin E supplementation to simvastatin therapy on vasoreactivity of the brachial artery of hypercholesterolemic men,” J. Am. Coll. Cardiol., vo. 32, No. 3 (1998) pp. 711-716.
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Geriat. Med., vol. 19, No. 3, 415-422 (1981).
Suzumura et al., “Inhibitory Effects of Fluvastatin and Its Metabolites on Hydrogen Peroxide-Induced Oxidative Destruction on Hemin and Low-Density Lipoprotein”,Biol. Pharm. Bull. 23 (7) 973-878, Jul. 2000.
Cighetti et al., “Modulation of HMG-CoA reductase activity by pantetheine/pantethine”,Biochimica et Biophysica Acta, 963(2), 389-393, Nov. 25, 1988.
Bellentani et al., “Taurine increases bile acid pool size and redues bile saturation index in the hamster”,Journal of Lipid Research, vol. 28(9), 1021-1027, Sep. 1987.

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