Blood group antigen panel

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 71, 435960, 436501, 436548, 436 63, 436811, 436813, 436510, G01N 33574, G01N 33571

Patent

active

051680432

ABSTRACT:
The subject invention describes a method of determining the secretor status of an individual which comprises obtaining a sample of a biological fluid from the individual and determining whether the sample includes the Lewis.sup.a or Lewis.sup.b antigens, the presence of the Lewis.sup.a antigen in the sample indicating that the individual is a nonsecretor, the presence of the Lewis.sup.b antigen in the sample indicating that the individual is a secretor, and the presence of neither antigen indicating the secretor status of the individual is inconclusive. The invention also provides a method of further determining the secretor status of an individual of having an inconclusive secretor status which comprises determining whether the biological fluid sample from the individual includes A, B or precursor type 1 chain antigens, the presence of any such antigens in the sample indicating that the individual is a secretor, the lack of any such antigens in the sample indicating that the individual is a nonsecretor. The invention provides a method of determining whether a human female subject is susceptible to urogenital infection which comprises determining whether the subject is a secretor according to the hereinabove-described methods, a secretor being susceptible to such an infection. The present application also provides a method of disstinguishing urothelial carcinoma from normal tissue, and identifying human germ cell tumor as seminoma or nonseminoma. Finally, the invention provides a panel comprising some or all of the monoclonal antibodies H 29-36 (ATCC No. HB 8248), S8 (ATCC No. HB 9036), T 174 (ATCC No. HB 8242), T 218 (ATCC No. HB 8249), P 12 (ATCC No. HB 8551), F 3 (ATCC No. HB 8217), and K 21 (ATCC No. HB 8549).

REFERENCES:
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Rettig, Wolfgang J., et al., Cancer Research, vol. 46, 1985, pp. 815-820.
Sakamoto, Junichi, et al., Biological Abstracts, vol. 79(10), Abstract No. 86505, 1984.
Cordon-Cardo, Carlos, et al., Biological Abstracts, vol. 83(3) Abstract No. 24317, 1986.
Motzer, Robert J., et al., Biological Abstracts, vol. 86(10), Abstract No. 104687, 1988.
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Issitt, Peter D., et al., Applied Blood Group Serology, Second Edition, 1977, Spectra Biologicals, pp. 91-92.

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