Blood fractionation system and method

Liquid purification or separation – Casing divided by membrane into sections having inlet – Membrane movement during purification

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

2104161, B01D 6122

Patent

active

054645344

ABSTRACT:
A system for separating at least one constituent from a liquid suspension such as blood induces high velocity flow by viscous drag about the circumference of a spinner having a filtration membrane with pore sized selected for the desired constituent. The high velocity circumferential flow is bounded by a spaced apart shear wall, with a spacing selected relative to the diameter of the spinner and its rotational velocity, also with respect to the viscosity of the suspension, to establish a flow within the shear gap, as substantial centrifugal forces are exerted upon the suspension. Under these conditions, filtrate in contact with the membrane is replenished and filtrate passes through the membrane with minimal adverse effects from deposition and concentration polarization, and with high efficiency because of high shear levels that are maintained. The filtrate is collected within the interior of the spinner in a conduit system and passed to an outlet orifice.

REFERENCES:
patent: Re31688 (1984-09-01), Popovich et al.
patent: 1664769 (1928-04-01), Chance
patent: 2197509 (1940-04-01), Reilly et al.
patent: 2398233 (1946-04-01), Lincoln
patent: 2670849 (1954-03-01), Dunmire
patent: 2709500 (1955-05-01), Carter
patent: 3026871 (1962-03-01), Thomas
patent: 3183908 (1965-05-01), Collings
patent: 3355382 (1967-11-01), Huntington
patent: 3396103 (1968-06-01), Huntington
patent: 3491887 (1970-01-01), Maestrelli
patent: 3523568 (1970-08-01), Van Leeuwen
patent: 3568835 (1971-03-01), Hansen
patent: 3634228 (1972-01-01), Latham, Jr.
patent: 3647632 (1972-03-01), Johnson et al.
patent: 3674440 (1972-07-01), Kitrilakis
patent: 3705100 (1972-12-01), Blatt et al.
patent: 3771658 (1973-11-01), Brumfield
patent: 3771899 (1973-11-01), Brumfield
patent: 3821108 (1974-06-01), Manjikian
patent: 3830372 (1974-10-01), Manjikian
patent: 3847817 (1974-11-01), Jarman
patent: 3883434 (1975-05-01), Gayler
patent: 3900398 (1975-04-01), Gillette
patent: 3977976 (1976-12-01), Spaan et al.
patent: 4040965 (1977-08-01), Kohibes
patent: 4062771 (1977-12-01), Saupe
patent: 4066554 (1978-02-01), Guyer
patent: 4093552 (1978-06-01), Guyer
patent: 4113614 (1978-09-01), Rollo et al.
patent: 4184952 (1980-01-01), Stewart
patent: 4191182 (1980-03-01), Popovich et al.
patent: 4212741 (1980-07-01), Brumfield
patent: 4212742 (1980-07-01), Solomon et al.
patent: 4379452 (1983-04-01), DeVries
patent: 4412553 (1983-11-01), Kopp et al.
patent: 4443333 (1984-04-01), Mahurkar
patent: 4490135 (1984-12-01), Troutner
patent: 4493693 (1985-01-01), Bilstad et al.
patent: 4535062 (1985-08-01), Muller
patent: 4713176 (1987-12-01), Schoendorfer et al.
Smeby, "The Taylor-Vortex Membrane Oxygenator", Stratchchyde Bioengineering Seminars, Artificial Organs, University Park Press, RM Kenedi pp. 70-82.
Colton, "Fundamentals of Gas Transport in Blood", Artificial Lungs for Acute Respiratory Failure-Theory and Practice, Zapol & Qvist, Academic Press, N.Y. 33-41 (1976).
Kitrilakis et al., "A Rotary Disk Membrane Oxygenator", Artificial Lungs for Acute Respiratory Failure-Theory and Practice, Zapol & Qvist, Academic Press, N.Y., pp. 211-221 (1976).
Kozinski et al., "Protein Ultrafiltration: A General Example of Boundary Layer Filtration", AlChE Journal (vol. 18, No. 5) Sep. 1972, pp. 1030-1040.
A. K. Bhagat/C. R. Wilke, "Filtration Studies with Ultrafine Particles", Sep. 1966, University of California, Lawrence Radiation Laboratory, Berkeley, Calif., UCRl-16574, preprint released for announcement in Nuclear Science Abstracts.
A. K. Bhagat/CR Wilke, "Engineering Analysis of the Rotorfermentor", Aug. 1971, paper presented at annual meetings of the Soc. for Industrial Microbiology Aug. 29-Sep. 4, 1971, Colorado State University.
W. Tobler, "Dynamic Filtration-The Engineering Concept of the Escher Wyss Pressure Filter," Nov./Dec. 1979, Filtration & Separation, pp. 630-632.
J. Lieberherr, "Hydrodynamics of Annular Gap Flow Between Permeable Cylinder Walls", Escher Wyss Mitteilungen, Feb. 1978-Jan. 1979, 24-30.
A. Werynski et al., "Membrane Plasma Separation: Toward Improved Clinical Operation", Trans. Am. Soc. Artificial Internal Organs, vol. XXVII 1981, pp. 539-543.
K. Schindhelm et al., "Mass Transfer Characteristics of Plasma Filtration Membranes," Trans. Am. Soc. Artificial Organs, vol. XXVII 1981, pp. 554-558.
Forstrom et al., Formed Element Deposition onto Filtering Walls, Trans. Amer. Soc. Artif. Internal Organs, 21:602 (1974).
F. Castino et al., The Filtration of Plasma from Whole Blood: A Novel Approach to Clinical Detoxification, Artificial Kidney, Artif. Liver, and Artif. Cells, NE: Plenum Press.
A. Solomon et al., "Continuous Flow Membrane Filtration of Plasma from Whole Blood," Trans. Amer. Soc. Artif. Internal Organs, 24:21 (1978).
T. B. Wittbans et al., "Filtration Plasmapheresis in Vivo", Transfusion, vol. 21, No. 5, pp. 502-510.
B. A. Solomon, "Membrane Solutions: Technological Principals and Issues", Trans Am. Soc. Artif. Internal Organs, 1981, pp. 345-350.
A. L. Zydney et al., "Continuous Flow Membrane Plasmapheresis: Theoretical Modes for Flux & Hemolysis Prediction", Trans. Am. Soc. Artif. Internal Organs, pp. 408-412.
G. I. Taylor, "Stability of a Viscous Liquid Contained Between Rotating Cylinders", Phil. Trans. Roy. Soc.: A, 223:289 (1923).
G. I. Taylor, "Distribution of Velocity & Temperature Between Concentric Rotating Cylinders", Phil. Trans. Roy. Soc.:A, 151:494 (1932).
H. Schlichting, "Boundary-Layer Theory", pp. 500-509,521-522, McGraw-Hill, N.Y. 1968.
A. L. Robinson, "How Does Fluid Flow Become Turbulant", Science, 221:140, Jul. 1983.
J. D. S. Gaylor et al. "Gas Transfer & Thrombogenesis in an Annular Membrane Oxygenator with Active Blood Mixing", vol. XIX, Trans. Am. Soc. Artif. Organs, 1973, pp. 516-524.
T. W. Wood Thesis in Deposition of Red Blood Cells onto Filtering Surfaces-Univer. of Minn. 1914.
A. B. Strong et al., "An Experimental Study of Mass Transfer in Rotating Conette Flow with Low Axial Reymolds Number," The Canadian Journal of Chem. Eng., vol. 54, Aug. 1976, pp. 295-298.
E. C. Eckstein et al., "Self-Diffusion of Particles in Shear Flow of a Suspension", J. Fluid Mech (1970 vol. 79, part a., pp. 191-208).
T. K. Sherwood et al., "Desalination by Reverse Osmosis", Fundamentals, vol. 6, No. 1, Feb. 1967, pp. 2-12.
Hallstrom & Lopez-Levia, "Description of a Rotating Ultrafiltration Module" Desalination, Netherlands 24 (1978) 273-279.
Lopez-Leiva, "Ultrafiltration at Low Degrees of Concentration Polarization: Technical Possibilities", Desalination, Netherlands 1980.
K. A. Kraus, "Cross Flow Filtration and Axial Filtration", (unknown original and date). pp. 1059-1075.
C. R. Wilke et al., "Filtration Studies with Ultrafine Particles", University of California UCRL-16574 Sep. 1966, p. 106.
Lopez-Levia PHD Dissertation, "Ultrafiltration in Rotary Annular Flow", Dec. 1979, Div. of Food Eng., Lund University, Sweden.
W. Tobler, "Dynamic Filtration: Principal & Application of Shear Filtration in an Annular Gap", Filtration & Separation, Jul. 8, 1982, pp. 329-333.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Blood fractionation system and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Blood fractionation system and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Blood fractionation system and method will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-195147

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.