Blood fractionation method

Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...

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21032168, 210650, 604 4, B01D 6122, B01D 6114, A61M 134

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active

057830851

ABSTRACT:
A system for separating at least one constituent from a liquid suspension such as blood induces high velocity flow by viscous drag about the circumference of a spinner having a filtration membrane with pore sized selected for the desired constituent. The high velocity circumferential flow is bounded by a spaced apart shear wall, with a spacing selected relative to the diameter of the spinner and its rotational velocity, also with respect to the viscosity of the suspension, to establish a flow within the shear gap, as substantial centrifugal forces are exerted upon the suspension. Under these conditions, in contact with the membrane and filtrate passes through the membrane is replenished with minimal adverse effects from deposition and concentration polarization, and with high efficiency because of high shear levels that are maintained. The filtrate is collected within the interior of the spinner in a conduit system and passed to an outlet orifice.

REFERENCES:
patent: Re31688 (1984-09-01), Popovich et al.
patent: 1664769 (1928-04-01), Chance
patent: 2197509 (1940-04-01), Reilly et al.
patent: 2398233 (1946-04-01), Lincoln
patent: 2670849 (1954-03-01), Dunmire
patent: 2709500 (1955-05-01), Carter
patent: 3026871 (1962-03-01), Thomas
patent: 3183908 (1965-05-01), Collings
patent: 3355382 (1967-11-01), Huntington
patent: 3396103 (1968-08-01), Huntington
patent: 3491887 (1970-01-01), Maestrelli
patent: 3523568 (1970-08-01), Van Leeuwen
patent: 3568835 (1971-03-01), Hansen
patent: 3634228 (1972-01-01), Latham, Jr.
patent: 3647440 (1972-03-01), Kitrilakis
patent: 3647632 (1972-03-01), Johnson et al.
patent: 3705100 (1972-12-01), Blatt et al.
patent: 3771658 (1973-11-01), Brumfield
patent: 3771899 (1973-11-01), Brumfield
patent: 3821108 (1974-06-01), Manjikian
patent: 3830372 (1974-08-01), Manjikian
patent: 3847817 (1974-11-01), Jarman
patent: 3883434 (1975-05-01), Gayler
patent: 3900398 (1975-08-01), Gillette
patent: 3977976 (1976-08-01), Spaan et al.
patent: 4040965 (1977-08-01), Kohibes
patent: 4062771 (1977-12-01), Saupe
patent: 4066554 (1978-01-01), Guyer
patent: 4093552 (1978-06-01), Guyer
patent: 4184952 (1980-01-01), Stewart
patent: 4191182 (1980-03-01), Popovich et al.
patent: 4212741 (1980-07-01), Brumfield
patent: 4212742 (1980-07-01), Solomon et al.
patent: 4535062 (1985-08-01), Muller
patent: 5034135 (1991-07-01), Fischel
Smebly, The Taylor-Vortex Membrane Oxygenator;, Stratchchyde Bioengineering Seminars, Artificial Organs, University Park Press, RM Kenedi pp. 70-82, (undated).
Colten, "Fundamentals of Gas Transport in Blood", Artificial Lungs for Acute Respirator Failure-Theory and Practice, Zaplo & Qvist, Academic Press, NY, pp. 33-41 (1976).
Kitrilakis et al., "A Rotary Disk Membrane Oxygenator", Artificial Lungs for Acute Respiratory Failure-Theory and Practice, Zapol & Qvist, Academic Press, NY, pp. 211-221 (1976).
Kozinski et al., "Protein Ultrafiltration: A General Example of Boundary Layer Filtration", Alche Journal (vol. 18, No. 5) Sep. 1972, pp. 1030-1040.
AK Bhagat/C.R. Wilke, "Filtration Studies with Ultrafine Particles", 9/66, University of California, Lawrence Radiation Laboratory, Berkeley, CA, UCRL-16574, preprint release for announcement in Nuclear Science Abstracts.
AK Bhagat/CR Wilke, "Engineering Analysis of the Rotofermentor", Aug. 1971, paper presented at annual meeting of the Soc. for Industrial Microbiology, Aug. 29-Sep. 4, 1971, Colorado State University.
W. Tobler, "Dynamic Filtration-The Engineering Concept of the Escher Wyss Pressure Filter." Nov/Dec 1979, Filtration & Separation, pp. 630-632.
J. Lieberherr, "Hydrodynamics of Annular Gap Flo Between Permeable Cylinder Walls", Escher Wyss Mitteilungen, Feb. 1978-Jan. 1979, 24-30.
A. Werynski et al., "Membrane Plasma Separation: Toward Improved Clinical Operation," Trans. Am. Soc. Artificial Internal Organs, vol. XXVII 1981, pp. 539-543.
K. Schindhelm et al.: Mass Transfer Characteristics of Plasma Filtration Membranes, Trans Am. Soc. Artificial Organs, vol. XXVII 1981, pp. 554-558.
Forstrom et al., Formed Element Deposition onto Filtering Walls, Trans. Amer. Soc. Artificial Organs, 21:602 (1974).
F. Castino et al., The Filtration of Plasma from Whole Blood: A Novel Approach to Clinical Detoxification, Artificial Kidney, Artificial Liver, and Artificial Cells, NE: Plenum Press, (undated).
A. Solomone et al., Continuous Flow Membrane Filtration of Plasma from Whole Blood, Trans Amer. Doc. Artif. Internal Organs, 24:21 (1978).
TB Wittbans et al., Filtration Plasmapheresis in Vivo,: Tranfusion, vol. 21, No. 5, pp. 502-510, (undated).
BA Solomon, "Membrane Solutions: Technological Principals and Issues", Trans Am Soc Artif Internal Organs, 1981, pp. 345-350.
Al Zydney et al., "Continuous Flow Membrane Plasmapheresis: Theoretical Modes for Flux & Hemolysis Prediction", Trans Am Soc Artif Internal Organs, pp. 408-412, (undated).
GI Taylor, "Stability of a Viscous liquid Contained Between Rotating Cylinders", Phil Trans Roy Soc: A, 223:289(1923).
GI Taylor, "Distribution of Velocity & Temperature Between Concentric Rotating Cylinder", Phil Trans Roy Soc: A, 151:494 (1932).
J. Schlichting, "Boundary-Layer Theory", pp. 500-509, 521-522, McGraw-Hill, NY 1968.
Al Robinson, "How Does Fluid Flow Become Turbulent", Science, 221:140, Jul 1983.
JDS Galyor et al., Gas Transfer & Thrombogenesis in an Annular Membrane Oxygenator with Active Blood Mixing, vol. XIX, Trans Am Soc Artif Organs, 1973 pp. 516-524.
TM Wood Thesis in Deposition of Red Blood Cells onto Filtering Surfaces, Univer. of Minn. 1914.
AB Strong et al., "An Experimental Study of Mass Transfer in Rotating Coneote Flow with Low Axial Reynolds Number", The Canadian Journal of Chem. Eng., vol. 54, Aug. 1976, pp. 295-298.
EC Eckstein et al., Self-Diffusion of Particles in Shear Flow of a Suspension J. Fluid Mech (1970) vol. 79 part a., pp. 191-209.
TK Sherwood et al., "Desalination by Reverse Osmosis", Fundamentals vol. 6, No. 1, Feb. 1967, pp. 2-12.
Hallstrom & Lopez-Leiva, "Description of a Rotating Ultrafiltration Module" Desalination, Netherlands 24 (1978) 273-279.
Lopez-Leiva, "Ultrafiltration at Low Degrees of Concentration Polarization, Technical Possibilities", Desalination, Netherlands 1980.
KA Klaus, "Cross Flow Filtration and Axial Filtration", (unknown original and date) pp. 1059-1075.
CR Wilke et al., "Filtration Studies with Ultrafine Particles", University of California UCRL-16574 Sep. 1966, p. 106.
Lopez-Leiva PH.D. Dissertation, "Ultrafiltration in Rotary Annular Flow,"Dec. 1979, Div. of Food Eng., Lund University, Sweden.
W. Tobler, "Dynamic Filtration: Principal & Application of Shear Filtration in an Annular Gap", Filtration & Separation, Jul. 8, 1982 pp. 329-333.

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