Blood fractionation

Details Blood fractionation Blood fractionation

1975-12-11

1978-03-28

Danison, Walter C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424101, A23T 106

Patent

active

040814319

ABSTRACT:
A process for the fractionation of blood comprising passing said blood through a cation exchanger, separating the solids from the plasma, freezing the plasma, thawing the frozen plasma, and separating a first product comprising undissolved cryoprecipitate enriched in factor-VIII protein from plasma fluid. The cryoprecipitate can be concentrated by warm water dissolution and polyethylene glycol precipitation. The plasma fluid, optionally after treatment with .beta.-propiolactone and uv irridiation, is treated with tricalcium phosphate to adsorb factors II, VII, IX and X as a second product. These factors can be eluted with citrate solution. The residual plasma from the initial tricalcium phosphate adsorption is treated with colloidal silica to adsorb impurities and leave a third product which is a storage-stable serum protein solution.

REFERENCES:
patent: 3652530 (1972-03-01), Johnson et al.
patent: 3682881 (1972-08-01), Fekete et al.
patent: 3869436 (1975-03-01), Falksveden
patent: 3916026 (1975-10-01), Stephan
patent: 3920625 (1975-11-01), Andersson et al.
patent: 3973002 (1976-08-01), Hagan et al.
Laursen et al., Chemical Abstracts, vol. 67:50,325p (1967).
Reid et al., Ind. & Eng. Chem., vol. 43, No. 5 (1951), pp. 1074-1075.
Tullis et al., The New England Journal of Medicine, vol. 273, No. 13 (1965), pp. 667-674.

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