Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1984-02-23
1988-05-17
Kepplinger, Esther M.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436520, 436522, 436536, 436821, 436829, 436825, G01N 33536, G01N 33543, G01N 33555
Patent
active
047450746
ABSTRACT:
A blood fluid composition for use in a complement-mediated cell lysis system. The composition includes a blood fluid, which may be either a serum source of complement, analyte-containing serum, or both, and lipid vesicles capable of reducing the extent of non-specific cell lysis produced when the blood fluid is added to lysable target cells in the system. The vesicles are present in an amount which increases the ratio of ligand-specific to non-specific cell lysis in the system at least 2-fold and preferably 4-fold or more over that achievable in the system in the absence of the vesicles.
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Benjamin Geiger, et al., Immunochemical Determination of Ganglioside GM2, by Inhibition of Complement-Dependent Liposome Lysis, Journal of Immunological Methods, 17 (1977) 7-19, Elsevier/North-Holland Biomedical Press pp. 7-19.
Kung Viola T.
Martin Francis J.
Schreier Hans
Szoka Francis C.
Cooper-Lipotech Partnership
Kepplinger Esther M.
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