Blood-fluid composition for cell lysis system

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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436520, 436522, 436536, 436821, 436829, 436825, G01N 33536, G01N 33543, G01N 33555

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active

047450746

ABSTRACT:
A blood fluid composition for use in a complement-mediated cell lysis system. The composition includes a blood fluid, which may be either a serum source of complement, analyte-containing serum, or both, and lipid vesicles capable of reducing the extent of non-specific cell lysis produced when the blood fluid is added to lysable target cells in the system. The vesicles are present in an amount which increases the ratio of ligand-specific to non-specific cell lysis in the system at least 2-fold and preferably 4-fold or more over that achievable in the system in the absence of the vesicles.

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Mold et al., J. Immunol., 125(2):696-700 (1980).
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Mattiasson et al., in Enzyme--Immunoassay, Maggio (Ed.), CRC Press, Inc., Boca Raton, Fla., 232 (1980).
Szoka et al., Proc. Nat'l. Acad. Sci. USA 75(9):4194-4198 (1978).
Benjamin Geiger, et al., Immunochemical Determination of Ganglioside GM2, by Inhibition of Complement-Dependent Liposome Lysis, Journal of Immunological Methods, 17 (1977) 7-19, Elsevier/North-Holland Biomedical Press pp. 7-19.

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