Drug – bio-affecting and body treating compositions – Live hair or scalp treating compositions – Polymer containing
Patent
1996-10-21
1999-11-02
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Live hair or scalp treating compositions
Polymer containing
424401, 514880, 514881, A61K 706
Patent
active
059765151
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The present invention relates to a blood flow amount-improving agent, and to cosmetics containing it. In particular, the present invention relates to a blood flow amount-improving agent comprising a steroid derivative, and to cosmetics containing it, the cosmetics including, for example, a cosmetic for hair which is excellent in hair-growing effect, and a cosmetic for skin which is excellent in skin-beautifying effect.
BACKGROUND ART
Many people hope to permanently maintain plentiful, natural, and beautiful hairs on heads, regardless of young or old, or men or women. However, people suffer a lot of stresses in the modern society, such as social stresses and stresses concerning personal relationships. Such stresses badly affect hairs on heads, resulting in rapid increase, year by year, in the number of people who suffer from troubles concerning hairs on heads, such as alopecia. In response to such a situation, hair-growing agents have been hitherto developed, including, for example, extracts from galenicals such as Coicis semen, ginkgo, and ginger; vitamin E; alloxazine; and adenosine-3',5'-cyclic monophosphate (c-AMP). Any of these pharmaceuticals is known to have a function to improve the blood flow amount in minute peripheral blood vessels. It is considered that their hair-growing effects also result from such a function.
Among the hair-growing agents having the function as described above, the extracts from galenicals such as Coicis semen, ginkgo, and ginger are also known to have an effect on skin to improve a dermal state by improving the blood flow amount as well.
As described above, it is known for the cosmetic that the improvement in blood flow amount in minute peripheral blood vessels results in preferred effects such that the hair growth is facilitated on skin of head, and the dermal state is improved on skin of body.
However, any of the hair-growing agents described above is not fully sufficient in the hair-growing function. In addition, some of them are not preferable from a viewpoint of safety since adverse side effects such as dermatitis are caused as in the case of so-called 101 which brought about a boom. In general, no hair-growing agent capable of being put to practical use without any problem has been obtained until now. The skin cosmetics also have had their insufficient functions, being not suitable for practical use if they are evaluated also from the viewpoint of safety.
Thus it has been desired to develop a blood flow amount-improving agent which has an excellent function to improve the blood flow amount and has high safety, in order to obtain a cosmetic for hair which is excellent in the hair-growing effect, and a cosmetic for skin which is excellent in the function to improve the dermal state.
On the other hand, it has not been known that steroid derivatives as represented by general formulae (1) and (2) described below have the function to improve the blood flow amount. I n addition, it has not been reported that they are blended with a cosmetic for hair or a cosmetic for skin so that the hair growth is facilitated, or the dermal state is improved.
DISCLOSURE OF THE INVENTION
The present invention has been made taking the viewpoints described above into consideration, an object of which is to provide a blood flow amount-improving agent which has an excellent blood flow amount-improving function and has high safety, and cosmetics containing it such as a cosmetic for hair which is excellent in the hair-growing effect, and a cosmetic for skin which is excellent in the skin-beautifying effect.
As a result of extensive and repeated screening for various pharmaceuticals and chemicals by the present inventors in order to achieve the object described above, it has been found that steroid derivatives represented by the following general formula (1) or (2) not only have high safety but also have an excellent blood flow amount-improving function. Thus the present invention has been completed.
Namely, the present invention lies in a blood flow amount-improving agent co
REFERENCES:
patent: 5198225 (1993-03-01), Meybeck et al.
Inaoka et al., Chemical Abstracts, vol. 123, #122840, 1994.
Ohsawa et al . Studies on constituents of fruit body of Polyporous umbellatus and their cytotoxic activity. Chem. Pharm. Bull. vol. 40 (1), pp. 143-147, 1992.
Inaoka Yasunori
Okada Masanori
Shibata Jun'ichi
Tsuji Kuniro
Channavajjala Lakshmi
Kuniro Tsuji
Page Thurman K.
Pola Chemical Industries Inc.
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