Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1996-06-06
1999-09-28
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 2, 435372, 435383, 436518, 436536, 530380, 530381, 530383, C12Q 156
Patent
active
059587164
ABSTRACT:
The present invention provides a method for indicating von Willebrand factor deficiency in a blood sample or platelet-rich plasma sample which exhibits abnormal platelet function comprising (a) adding a von Willebrand factor preparation to the sample, and (b) testing the sample for platelet function. In this method, the von Willebrand factor preparation restores normal platelet function and indicates that the sample initially lacked the von Willebrand factor. The von Willebrand factor preparation comprises purified von Willebrand factor. The invention also discloses a method which further comprises separating the blood sample into a plasma layer and cellular component layer and removing the plasma layer, prior to the step of adding a von Willebrand factor preparation to the sample. In this embodiment the von Willebrand factor preparation comprises platelet-poor plasma containing a normal level of von Willebrand factor. The invention further provides a kit for indicating von Willebrand factor deficiency in a blood sample which exhibits abnormal platelet function comprising a von Willebrand factor preparation, wherein the preparation is added to the sample and restores normal platelet function, indicating that the sample initially lacked the von Willebrand factor.
REFERENCES:
patent: 2616796 (1952-11-01), Schilling et al.
patent: 3219421 (1965-11-01), Schwartz, Jr. et al.
patent: 3267362 (1966-08-01), Page
patent: 3267364 (1966-08-01), Page et al.
patent: 3268804 (1966-08-01), Young
patent: 3539300 (1970-11-01), Stone
patent: 3605010 (1971-09-01), Folus
patent: 3694161 (1972-09-01), Kleszynski et al.
patent: 3914985 (1975-10-01), von Behrens
patent: 3918908 (1975-11-01), Moyer et al.
patent: 4281061 (1981-07-01), Zuk et al.
patent: 4451568 (1984-05-01), Schneider et al.
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4533519 (1985-08-01), Baugh et al.
patent: 4534939 (1985-08-01), Smith et al.
patent: 4599219 (1986-07-01), Cooper et al.
patent: 4604894 (1986-08-01), Kratzer et al.
patent: 4663127 (1987-05-01), Jackson et al.
patent: 4752449 (1988-06-01), Jackson et al.
patent: 4777141 (1988-10-01), Calzi et al.
patent: 4780418 (1988-10-01), Kratzer
patent: 4784944 (1988-11-01), Kolde
patent: 4788139 (1988-11-01), Ryan
patent: 4812293 (1989-03-01), McLaurin et al.
patent: 4865813 (1989-09-01), Leon
patent: 4983514 (1991-01-01), Weithmann et al.
patent: 5047211 (1991-09-01), Sloane, Jr. et al.
patent: 5051239 (1991-09-01), von der Goltz
patent: 5089422 (1992-02-01), Brubaker
patent: 5091304 (1992-02-01), La Duca et al.
patent: 5093237 (1992-03-01), Enomoto
patent: 5111946 (1992-05-01), Glanz
patent: 5128104 (1992-07-01), Murphy et al.
patent: 5139944 (1992-08-01), Sawyer et al.
patent: 5140161 (1992-08-01), Hillman et al.
patent: 5174961 (1992-12-01), Smith
patent: 5187102 (1993-02-01), Stocker et al.
patent: 5196403 (1993-03-01), Maraganore et al.
patent: 5197017 (1993-03-01), Carroll et al.
patent: 5221614 (1993-06-01), Enomoto
patent: 5223227 (1993-06-01), Zuckerman
patent: 5246666 (1993-09-01), Vogler et al.
patent: 5246715 (1993-09-01), Orevi et al.
patent: 5275953 (1994-01-01), Bull
patent: 5281661 (1994-01-01), Linnau et al.
patent: 5314826 (1994-05-01), Baugh
patent: 5316730 (1994-05-01), Blake et al.
patent: 5339830 (1994-08-01), Blake, III
patent: 5352413 (1994-10-01), Kratzer et al.
patent: 5366869 (1994-11-01), Goldstein et al.
patent: 5427913 (1995-06-01), Shaw et al.
patent: 5460779 (1995-10-01), Kratzer et al.
patent: 5569590 (1996-10-01), Speck
"PFA Reagents", Dade.
"Thromboplastin-C; Dried Rabbit Brain Thromboplastin with Calcium For use in prothrombin time (PT) determinations and prothrombin time based assays", Baxter.
Activated Cephaloplastin Reagent--Liquid Rabbit Brain Cephalin with Plasma Activator, Baxter.
Product inclosure: Repllplate--American Diagnostica Inc., 1991.
Product inclosure--Bio/Data Corporation, 1981.
Product inclosure: Purified Human vWF--American Diagnostica Inc., 1993.
"Platelet Function Analyzer PFA-100", Baxter.
Colman et al., Hemostasis and Thrombosis, Basic Principles and Clinical Practice, pp. 143-149.
Allain et al., J. Lab. Clin. Med, 1975, "Platelets fixed with paraformaldehyde: a new reagent for assay of von Willebrand factor and platelet aggregating factor", pp.318-328.
Miller et al., J. Clin. Invest., The American Society for Clinical Investigation, Inc., vol. 72, 1983, pp. 1532-1542.
Kratzer et al., Haemostasis, 15:357-362 (1985), "Simulation of Primary Haemostasis In Vitro".
Kratzer et al., Haemostasis, 15:363-370 (1985), "Detection of Abnormal Platelet Functions With an In Vitro Model of Primary Haemostasis".
Weiss et al., Blood,vol. 68, No. 1, 1986, pp. 149-156.
Maurin, The International Journal Of Artificial Organs, vol. 11, No. 4, (1988), "The In vitro Bleeding Time While Using A Stable Prostacyclin Analogue During Hemodialysis".
Tsujinaka et al., Japanese Journal Of Surgenry, vol. 18, No. 4, pp. 430-437, (1988), "Clinical Application of a New in vitro Bleeding Time Device on Surgical Patients".
Kretschmer et al., Blut, 59:188 (1989), "In Vitro Bleeding Test--A Sensitive Method For The Detection Of Platelet Function Impairment And A Potential Test For The Control Of Low-Dose Aspirin Efficacy".
Kretschmer et al., Thrombosis Research, 56:593-602 (1989), "In Vitro Bleeding Test--A Simple Method For The Detection Of Aspirin Effects On Platelet Function".
Dietrich et al., Infusionstherapie, 17:214-216 (1990), "Primary Hemostatis in Hemodilution--2) Infusion Solutions".
Alshameeri et al., Thromb. Haemost 1993, 69:1146, "Evaluation Of An In Vitro Bleeding Time Device, Thrombostat 4000".
Kretschmer et al., Transfus. Sci., 14:27-34 (1993), "Determination of Bleeding Risk in Thrombocytopenic Patients Receiving Platelet Substitution".
Dietrich et al., Lab. Med., 17:317-323, (1993), "The In Vitro Bleeding Test Standardization Of The Methodical Procedure".
Eriksson et al., Eur. J. Haematol., 51:152-155 (1993), "Functional Capacity Of Transfused Platelets Estimated By The Thrombostat 4000/2".
Kundu et al., Seminar in Thrombosis and Hemostasis, vol. 21, Suppl. 2, 1995, "Description of an In Vitro Platelet Function Analyzer-PFA-100", pp. 106-112.
Mammen et al., Seminar in Thrombosis and Hemostasis, vol. 21, Suppl. 2, 1995, "Preliminary Data from a Field Trial of the PFA-100 System", pp. 113-121.
Dade Behring Inc.
Graser Jennifer
Housel James C.
Lowen Cara Z
Ruszala Lois K
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