Chemistry: analytical and immunological testing – Composition for standardization – calibration – simulation,... – Particle count or volume standard or control
Patent
1982-12-30
1985-03-19
Padgett, Ben R.
Chemistry: analytical and immunological testing
Composition for standardization, calibration, simulation,...
Particle count or volume standard or control
436 15, 2524081, G01N 3316
Patent
active
045060185
ABSTRACT:
An improved multi-purpose blood diluent is provided which is isotonic, with a neutral pH for avoiding cell volume change. The diluent of the invention provides balance between the effects on cell volume of a preservative for the solution, and the effects of a surfactant. The diluent of the invention is particularly useful as a carrier for blood samples in instruments which automatically provide medical diagnostic determinations of blood samples. The diluent herein includes conventional sodium and potassium chlorides as electrolytes, pH buffers, such as monobasic and dibasic phosphate, and ethylene diamine tetraacetic acid to control and chelate the divalent cations. The balanced preservative-surfactant combination may include, for example, 2-phenoxyethanol with certain ethylene oxide-polypropylene glycol condensation products.
REFERENCES:
patent: 2674619 (1954-04-01), Lundsted
patent: 3450502 (1969-06-01), Hymes
patent: 3577522 (1971-05-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3850903 (1974-11-01), Garcia et al.
patent: 3915643 (1975-10-01), Gindler
patent: 3962125 (1976-06-01), Armstrong
patent: 4102810 (1978-07-01), Armstrong
patent: 4184848 (1980-01-01), Batz et al.
patent: 4229726 (1981-11-01), Crews et al.
patent: 4322313 (1982-03-01), Raaijmakers
patent: 4389490 (1983-06-01), Crews et al.
"Inhibitory Effect of Non-Ionic Detergents on Osmotic Lysis of Human Red Blood Cells", European J. Physiology, vol. 343, Suppl. Rl 1973.
"Desaggregation of Human Red Blood Cells . . . ", Acta haemat. 53: 82-89, (1975), Gaehtgens et al., Univ. of Koln, Koln.
"Combined and Individual Protection by Pluronic Polyols . . . ", Cryobiology, 11, 285-295, (1974), Voss et al.
Becton Dickinson and Company
Grindle R. P.
Padgett Ben R.
Wallen T. J.
LandOfFree
Blood diluent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Blood diluent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Blood diluent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-753570