Blood contact surfaces employing natural subendothelial matrix a

Details Blood contact surfaces employing natural subendothelial matrix a Blood contact surfaces employing natural subendothelial matrix a

1996-06-18

1998-06-09

Prebilic, Paul B.

Surgery

Blood vessel or graft preparation

623 1, 623 12, A61F 204

Patent

active

057626006

ABSTRACT:
This invention relates to improved vascular prostheses derived from mammalian blood vessels. The prostheses are fabricated from arterial segments from which the donor endothelium has been removed. A key aspect of this invention is the preservation of the subendothelial extracellular matrix that will serve as the blood interface of the vascular prostheses. The vessel segments are treated to reduce the likelihood of calcification and fixed with a tissue preservative. This invention results in vascular prostheses that are particularly useful for small diameter applications, such as arterial replacement requiring a diameter of 6 mm or less.

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