Blood coagulation protein antagonists and uses therefor

Details Blood coagulation protein antagonists and uses therefor Blood coagulation protein antagonists and uses therefor

1995-05-30

1998-12-01

Loring, Susan A.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241581, 5303887, 53038825, A61K 39395, C07K 1600, C07K 1618

Patent

active

058434429

ABSTRACT:
Coagulation protein antagonists are disclosed, which include monoclonal-type antibodies and related cell lines disclosed for the production of specific, neutralizing antibodies against factors VII and VIIa and the tissue factor/factor VIIa bimolecular complex, which antibodies are useful for the prevention or treatment of thrombotic and related diseases, for immunoaffinity isolation and purification of factors VII and VIIa and the tissue factor/factor VIIa complex, and for determination of factors VII or VIIa and the tissue factor/factors VII or VIIa complex in a biological sample.

REFERENCES:
patent: 4382083 (1983-05-01), Thomas
Carson et al, Blood, 70(2):490-493, Aug. 1987.
Takase et al, J. Clin Pathol, 41:337-341, 1988.
Higashi et al, J. Biochem, 108:654-662, 1990.
Drake et al, J. Cell Biol, 109:389-395, Jul. 1989.
Drake et al, Am J Pathol, 134(5):1087-1097, May 1989.

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