Blood-coagulation-promoting preparation based on human proteins

Details Blood-coagulation-promoting preparation based on human proteins Blood-coagulation-promoting preparation based on human proteins

1981-07-14

1983-07-26

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3514

Patent

active

043953964

ABSTRACT:
In a method of producing a blood-coagulation-promoting preparation based on human proteins and having a content of coagulation factors II, VII, IX and X and factor-VIII-inhibitor-bypassing-activity (FEIBA), human plasma is treated with sulphated high-polymer carbohydrates and/or with basic ion exchangers, the protein mixture with generated FEIB-activity is adsorbed on the ion exchanger, and the preparation is gained by elution and concentration.

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patent: 4170590 (1979-10-01), Stephan et al.
patent: 4286056 (1981-08-01), Andary et al.
patent: 4287180 (1981-09-01), Thomas
Pepper, D. S., et al., "Chromatography of Human Prothrombin Complex of Dextran Sulphate Agarose", Thrombosis Research, vol. 11, pp. 687-692, 1977.
Proc. Natl. Acad. Sci., U.S.A., vol. 74, No. 7, pp. 3028-3032, Jul. 1977 Medical Sciences.
Gitel, G. N. et al., "In Vitro and in Vivo Correlation of Clotting Protease Activity: Effect of Heparin", Proc. Natl. Acad. Sci. USA, vol. 74, No. 7, pp. 3028-3032, Jul. 1977.
Alving, B. M. et al., "Hypotension Associated with Prekallikrein Activator (Hageman-Factor Fragments) in Plasma Protein Fraction", New England Journal of Medicine, pp. 66-70, Jul. 13, 1978.
Elsinger, F., Speech Delivered on Activated Prothrombin Complex Concentrates, The State of the Art of Managing Hemophilia with Factor VIII Inhibitor, Rome, Mar. 30-31, 1981.

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