Blood coagulation factors and process for their manufacture

Details Blood coagulation factors and process for their manufacture Blood coagulation factors and process for their manufacture

1980-04-23

1981-10-27

Cacciapaglia, Jr., Frank

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424176, 424177, 260122B, A61K 3514, A61K 3100, A61K 3700

Patent

active

042973449

ABSTRACT:
A process for stabilizing the coagulation factors II, VIII, XIII, antithrombin III and plasminogen against heat is described. The preparations obtained according to this process are practically free from coagulable fibrinogen.

REFERENCES:
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patent: 3732146 (1973-05-01), Heimburger
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Johnson, Blood, 28, 1011, (1966).
Bohn, Blut 25, 235-248 (1972).
Chem. Abstr., 77:71646r (1972) & 78:120553q (1973).
Schwick et al., "Antithrombin Uterine Hamostase Herz und Blutgerinnung", (1971), pp. 5-16.
Deutsch et al., Science, 170, 1095-1096 (1970).
Wagner et al., Thromb. Diath. Hamor., 11, 64-74 (1964).
Cohn et al., J. Am. Chem. Soc. 68 (1946), 459-475.
Gellis et al., J. Clin. Invest. 27, 239-244 (1948).
Pool et al., New Eng. J. Med., 273 (1965), 1443-1447.

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