Blood coagulation factor XI concentrate having high specific act

Details Blood coagulation factor XI concentrate having high specific act Blood coagulation factor XI concentrate having high specific act

1992-05-07

1993-10-12

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210656, 435 13, 436 69, 530381, 530416, 530417, B01D 1508

Patent

active

052522172

ABSTRACT:
The invention relates to a human Factor XI concentrate having high specific activity prepared using a process comprising a filtration-adsorption step and a single step of chromatography on cation exchange resin.
The concentrate obtained is perfectly suitable for therapeutic use in replacement therapy in cases of Factor XI deficiency.

REFERENCES:
patent: 4783262 (1988-11-01), Ostreicher et al.
patent: 4859340 (1989-08-01), Hou et al.
Journal of Bio. Chem., vol. 252, No. 18 (1977), pp. 6432-6437: Bouma et al.: Human Blood Coagulation Factor XI . . .
Throm. Res. 60; 87-97 (1990): Schiffman et al.: Purification and Characterization of Platelet Factor XI.
Winkelman et al. International Congress ISBT-BBTS, London, Jul. 1988: Production and Clinical Use of a Therapeutic Concentrate of Factor XI from Human Plasma Abstract #P-M-4-15.
Zeta Plus S Series Filter Media, Cuno Inc. 1990, pp. 1-6 Article #ZP, S01., 0490.
Zeta Plus Publication #ZP S01. 1288, Cuno Inc. 1988, pp. 5-13.
Biological Abstracts, vol. 65, Ref. 12893 (1978): Bouma et al. "Human blood Coagulation Factor XI".
Methods in Enzymology/Blood Clotting Enzymes pp. 65-73 (1975).

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