Blood clot filtering

Surgery – Instruments – Internal pressure applicator

Patent

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Details

A61B 1700

Patent

active

060130938

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

This invention relates to blood clot filtering.


BACKGROUND

Blood clots that form in the lower part of the body may migrate to the heart and may be subsequently pumped to the lungs. Small clots can be absorbed by the body without adverse effect. However, larger clots can interfere with the oxygenation of blood (e.g., on the order of 3 mm in diameter and 10-30 cm in length) and can possibly cause shock or sudden death.
Many transvenous filtering devices have been developed for installation in the vena cava to prevent especially large clots from reaching the lungs. These filters have fine wires positioned in the blood flow to catch and hold clots for effective lysing in the blood stream. Some of these devices are inserted into the vena cava by dissecting the internal jugular vein in the neck or the femoral vein in the groin, inserting a metallic capsule containing a filtering device to the proper position in the vena cava, and releasing the filtering device into the vena cava. More recently, filters have been designed for percutaneous introduction into the vasculature.


SUMMARY OF THE INVENTION

In one aspect, the invention features a filter sized and constructed to be compressed and passed through the vasculature of a patient to be anchored against an inner wall surface of a blood vessel for capturing blood clots in a blood stream passing therethrough. The filter comprises: an anchoring portion comprising a generally cylindrical self-expanding body formed from resilient material, the generally cylindrical body having proximal and distal ends and defining an axial direction and having a structure of variable size diameter expandable from a low-profile compressed condition to a larger profile expanded condition, wherein the resilient material urges the generally cylindrical body to radially expand and to thereby apply anchoring radial force against the inner wall surface of the blood vessel; and a generally conical filtering portion axially aligned with the generally cylindrical body having an open proximal end coupled to the distal end of the anchoring portion and having an apical distal end, the anchoring portion and the filtering portion being substantially non-overlapping to achieve a low profile compressed condition for delivery of the filter through the vasculature.
Embodiments of the invention may include one or more of the following features. The generally conical filtering portion is preferably formed from a plurality of elongated strands arranged to form a generally conical structure to guide blood clots in the blood stream flowing therepast to the apical distal end of the generally conical filtering portion for lysing. The elongated strands forming the generally conical filtering portion are constructed and arranged to maintain a generally conical shape whether the anchoring portion is in a compressed condition or an expanded condition. The anchoring portion and the filtering portion are preferably constructed and arranged so that the proximal end of the filtering portion conforms to the shape of the cylindrical body of the anchoring portion. The elongated strands are preferably fixedly attached to one another only at the apex of the generally conical filtering portion. The elongated strands may be formed from nitinol (nickel-titanium alloy), plastically deformable material, temperature-sensitive shape memory material with a transition temperature around body temperature, or elastic material having a core formed from radiopaque material. The filter may be coated with a drug for in vivo compatibility. The resilient elongated strands preferably extend from the proximal end of the anchoring portion to the distal apical end of the filtering portion.
The elongated strands of the filtering portion may define a plurality of neighboring filtering cells. According to one embodiment, the neighboring filtering cells are preferably loosely coupled together at the respective areas of contact between neighboring cells. The neighboring cells are preferably coupled together by helical tw

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Kraimps et al., "Conical Endocaval Filters with Metalltic Struts: Search for a New Model", Mar. 1992, Ann. Vasc. Surg., 6:99-110.
Kraimps et al., "Optimal Central Trapping (OPCETRA) Vena Caval Filter: Results of Experimental Studies", Nov. 1992, J. Vasc. and Inter. Rad., 3:697-701.

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