Blocking the effect of teratogens on a fetus

Details Blocking the effect of teratogens on a fetus Blocking the effect of teratogens on a fetus

1990-05-07

1992-03-31

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 31715

Patent

active

051008785

ABSTRACT:
By administration of sulfated cyclodextrin on a pregnant mother, the effect of a teratogen on a developing fetus is blocked. Blocking the effect of the teratogen reduces congenital defects in a developing fetus. The sulfated cyclodextrin has also been found to reduce the effect of the teratogen on a host. The sulfated cyclodextrin is administered either before or after onset of organogenesis and either before or after exposure to the teratogen. Teratogens include radiation, temperature extremes, chemicals, drugs, bacteria, viruses, hormones, stress, injury, pregnancy, and fatigue.

REFERENCES:
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Chemical Abstracts (92: 105205y) 1980.
J. Szejtli and G. Sebestyen, "Resorption, Metabolism and Toxicity Studies on the Peroral Application of beta-Cyclodextrin", Starch/Starke, 31, Nr. 11 (1979), pp. 385-389.
Chang et al., Dextran Sulfate as an Inhibitor against the Human Immunodeficiency Virus; Proceedings of the Society for Experimental Biology and Medicine 189, 304-309; Jul. 21, 1988.
Gerber; anti-Viral Compounds as Anti-Teratogens; Teratology-The Internation Journal of Abnormal Development; vol. 29, No. 2; Apr. 1984.
Folkman et al., Control of Angiogenesis with Synthetic Heparin Substitutes; vol. 243, pp. 1490-1493; Dec. 1988.
Beyer; A Study of Pharmacological Protection of Drug Induced Teratogenesis in the Fetal Hamster; Jun. 1984.

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