Blocking the attachment of germs to human cells

Details Blocking the attachment of germs to human cells Blocking the attachment of germs to human cells

1996-03-08

1997-11-04

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536114, 5361231, A61K 3173

Patent

active

056839910

ABSTRACT:
The invention concerns a pharmaceutical preparation which contains one or several galacturonides as the active substance with a degree of polymerization of .gtoreq.2 and a degree of esterification of <20% optionally together with common pharmaceutical carriers, diluents, auxiliary substances and fillers as well as the use of this preparation to block the attachment of germs to mammalian cells.

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patent: 5523014 (1996-06-01), Dolan et al.
Zopf et al., "Oligosaccharide Anti-Infective Agents," The Lancet, 347, 1017-1021 (Apr. 13, 1996).
H-J Gulzow, Praventive Zahnheilkunde--Grundlagen und Moglichkeiten der Karies und Gingivitisprophylaxe, Carl Hauser Verlag, Munchen, DE, 1995, only pp. 36-39 and 44-51 and translation into English of the last paragraphs from pp. 48, 51 supplied.
Biologia (Bratislava), 1991, pp. 1081-1087, K. Heinrichova, et al, "Preparation of oligo-(d-galactosiduronic) acids by the action of . . . " with Abstract.
Budavari et al. (eds.), The Merck Index, 11th Ed., Merck & Co., Rahway, NY, 1989, see Entry No. 4242 at pp. 678-679 (D-Galacturonic Acid) and Entry No. 6207 (Mucins) at p. 992.
Anderson & King, "Polysaccharides of the Characeae. Part VI. A Non-Esterified Pectic Acid from Nitella translucens," J. Chem. Soc., 1961 (Dec.), 5333-5338.
Kohn et al., "Binding of Cadmium and Copper(II) Ions to Oligogalacturonic Acids," Coll. Czech. Chem. Comm., 48(7), 1922-1935 (1983); Chem. Abstr., 99, Abstract No. 189127e (1983); Abstract supplied by applicant.
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