Blocking of device for detecting biochemically active molecules

Details Blocking of device for detecting biochemically active molecules Blocking of device for detecting biochemically active molecules

2005-02-22

2005-02-22

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S091100, C435S091200, C435S287200, C536S022100, C536S023100, C536S024300

Reexamination Certificate

active

06858392

ABSTRACT:
A process for blocking a device for detection of biochemically active molecules is performed by the steps of:bringing in the presence of an aqueous medium a detection device having probe molecules, ionic reactive groups, and non-ionic reactive groups on its surface, into contact with compounds which react with the non-ionic reactive groups to produce covalent bondings and compounds which form electrostatic bondings with the ionic reactive groups, simultaneously or separately; andwashing the surface of the detection device with an aqueous solvent or a water-miscible solvent.

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Van Ness J. et al., “A Versatile Solid Support System for Oligodeoxynucleotide Probe-Based Hybridization Assays,” Nucleic Acids Research, Oxford Univ. Press, vol. 19, No. 12.

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