Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2007-05-29
2007-05-29
Haddad, Maher M. (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S154100
Reexamination Certificate
active
10221758
ABSTRACT:
The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90%. In conjunction with PECAM inhibitors, TEM blockade approaches 100%. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.
REFERENCES:
patent: WO89/12690 (1989-12-01), None
patent: WO 96/27613 (1996-09-01), None
Bixel et al. Mouse CD99 participates in T-cell recruitment into inflamed skin. Blood. Nov. 15, 2004;104(10):3205-13.
Sherman-Gold, Gen. Eng. News 1993.
http://www-users.med.cornell.edu/˜jawagne/Antibody—Approaches.html, Making and using antibodies, May 31, 2005, pp. 1-7.
Norman and Kubes. Therapeutic intervention in inflammatory diseases: a time and place for anti-adhesion therapy. Microcirculation. Jan.-Feb. 2005;12(1):91-8.
Smith et al. “The Genomic Organisation of the Human Pseudoautosomal GeneMIC2and the Detection of a Related Locus”,Human Molecular Genetics(1993), vol. 2, No. 4, 417-422.
Bernard et al., “Apoptosis of Immature Thymocytes Mediated by E2/CD991”,The Journal of Immunology(1997), 158: 2543-2550.
Bernard et al., “The E2 Molecule (CD99) Specifically Triggers Homotypic Aggregation of CD4+CD8+Thymocytes”,The Journal of mmunology(1995), 154: 26-32.
Banting et a ., “TheMIC2Gene Product: Epitope Mapping and Structural Prediction Analysis Define An Integral Membrane Protein”,Molecular Immunology(1989), 26:(2) 181-188.
Hahn et al., “CD99 (MIC2) Regulates the LFA-1/ICAM-1-Mediated Adhesion of Lymphocytes, and Its Gene Encodes Both Positive and Negative Regulators of Cellular Adhesion1”The Journal of Immunology(1997), 159 (5) 2250-2258.
Petit et al., “Physical Mapping of the Human Pseudo-Autosomal Region; Comparison with Genetic Linkage Map”The EMBO Journal(1998) vol. 7, No. 8 2369-2376.
Dworzak et al., “Flow Cytometric Assessment of Human-MIC2 Expression In Bone Marrow, Thymus, and Peripheral Blood”Blood, (1994) vol. 83, No. 2 415-425.
Aubrit et al., “The Biochemical Characterization of E2, a T Cell Surface Molecule Involved in Rosettes”Eur. J. Immunol.(1989), 19:1431-1436.
Waclavicek et al., “CD99 Engagement on Human Peripheral Blood T Cells Results in TCR/CD3-Dependent Cellular Activation and Allows for Th1-Restricted Cytokine Production1”,The Journal of Immunology(1988), 161: 4871-4878.
Ellis et al., “PBDXis the XG Blood Group Gene”,Nature Genetics(1994), vol. 8, 285-290.
Muller et al , “Monocyte-Selective Transondothelial Migration: Dissection of the Binding and Transmigration Phases by an In Vitro Assay”,J. Exp. Med.(1992), vol. 176, 819-828.
Muller et a ., “A Human Endothelial Cell-Restricted, Externally Disposed Plasmalemmal Protein Enriched in Intercellular Junctions”,J. Exp. Med.(1989), vol. 170, 399-414.
Muller et al . “The Membrane Proteins of the Vacuolar System I. Analysis by a Novel Method fo Intralysosomal Iodination”,The Journal of Cel. Biology(1980), vol. 86, 292-303.
Muller et a ., “Plasmalemmal Proteins of Cultured Vascular Endothelial Cells Exhibit Apical-Basal Polarity: Analysis by Surface-Selective Indination”,The Journal of Cell Biology(1986), vol. 103, No. 6., 2389-2402.
Muller et al., “The Membrane Proteins of the Vascuolar System II. Bidirectional Flow between Secondary Lysosomes and Plasme Membrane”,The Journal of Cell Biology(1980), vol. 86, 304-314.
C. Gelin et al., “The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product,” EMBO Journal 11:3253-3259 (1989).
E. Y. Choi et al., “Engagement of CD99 Induces Up-Regulation of TCR and MHC Class I and II Molecules on the Surface of Human Thymocytes” Journal of Immunology, vol. 161, No. 2, pp. 749-754, Jul. 15, 1998.
G. S. Duncan et al., “Genetic Evidence for Functional Redundancy of Platelet/Endothelial Cell Adhesion Molecule-1 (FECAM-1): CD31-Deficient Mice Reveal PECAM-1-Dependent and PECAM-1-Independent Functions” Journal of Immunology, vol. 162, No. 5, pp. 3022-3030, Mar. 1, 1999.
D. Wingett et al., “A Role for CD99 in T Cell Activation” Cellular Immunology, vol. 193, No. 1, pp. 17-23, Apr. 10, 1999.
C. K. Park et al., “High CD99 Expression in Memory T and B Cells in Reactive Lymph Nodes” Journal of Korean Medical Science, vol. 14, No. 6, pp. 600-606, Dec. 1999.
Gabriele Bixel et al.; Mouse CD99 participates in T-cell recruitment into inflamed skin;Blood, Nov. 15, 2004;104(10): 3205-3213.
Christopher V. Carman, and Timothy A. Springer.; A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them;JCB; 2004;167(2): 378-388.
Muller William A.
Schenkel Alan R.
Cornell Research Foundation Inc.
Darby & Darby
Haddad Maher M.
LandOfFree
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