Blocking agents of EDRF effect or formation for the treatment of

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai

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514529, 514551, 514420, 514921, A61K 3122, A61K 3140, A61K 31215, A61K 31615

Patent

active

050811487

ABSTRACT:
The invention relates to a therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein, an effective amount either, of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.4 stant for H or CH.sub.3 or C.sub.2 H.sub.5,

REFERENCES:
BIOSIS #88127938, Aisaka et al L-Arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo.
Vallance et al. BIOSIS #89074491, Nitric oxide synthesized from L-arginine mediates endothelium dependent dilation in human vein in-vivo.

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