Blockade of T lymphocyte down-regulation associated with CTLA-4

Details Blockade of T lymphocyte down-regulation associated with CTLA-4 Blockade of T lymphocyte down-regulation associated with CTLA-4

1996-05-08

1998-09-22

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241331, 4241411, 4241431, 4241521, 4241541, 4241301, 4241351, 424810, 514 2, 514 12, 514885, 5303871, 5303873, 5303881, 53038822, 5303887, C07K 1628, C07K 14725, A61K 39395

Patent

active

058110976

ABSTRACT:
T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.

REFERENCES:
patent: 556763 (1896-09-01), Ochoa et al.
patent: 5434131 (1995-07-01), Linsley et al.
Damle et al., "Costimulation of T Lymphocytes with Integrin Ligands Intercellular Adhesion Molecule-1 or Vascular Cell Adhesion Molecule-1 Induces Functional Expression of CTLA-4, A Second Receptor for B7," Journal of Immunology 152:2686-2697 (1994).
Lin et al., "Long-Term Acceptance of Major Histocompatibility Complex Mismatched Cardiac Allografts Induced by CTLA4lg Plus Donor-Specific Transfusion," J. Exp. Med. 178:1801-1806 (1993).
Turka et al., "T-Cell Activation by the CD28 Ligand B7 is Required for Cardiac Allograft Rejection in vivo," Proc. Natl. Acad. Sci. USA 89:11102-11105 (1992).
Linsley, P.S. and J.A. Ledbetter, "The Role of the CD28 Receptor During T Cell Responses to Antigen," Ann. Rev. Immunol. 11:191-212 (1993).
Wu et al., "CTLA-4-B7 Interaction is Sufficient to Costimulate T Cell Clonal Expansion," J. Exp. Med. 185(7):1327-1335 (1997).
Linsley, P.S., "Distinct Roles for CD28 and Cytotoxic Lymphocyte-Associated Molecule-4 Receptors During T Cell Activation," J. Exp. Med., 182:289-292 (1995).
Walumas, TL et al Immunity 1:403-413, Aug. 1994.
Kearney ER et al J. Immunol 155:1032-1036 Aug. 1, 1995.

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