Blockade of sodium channels by phenol derivatives

Details Blockade of sodium channels by phenol derivatives Blockade of sodium channels by phenol derivatives

2001-11-13

2009-02-03

Padmanabhan, Sreeni (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

C514S731000

Reexamination Certificate

active

07485669

ABSTRACT:
The invention relates to a pharmaceutical composition comprising at least one phenol derivative represented by formula (I)whereinR1represents a hydrogen atom, a halogen atom or a hydrocarbon group containing up to 12 carbon atoms;R2represents a hydrogen atom or a C1-C7alkyl group; whereinR1and R2may optionally form a carbocyclic 5- or 6-membered ring;R3represents a hydrogen atom, a halogen atom or a C1-C7alkyl group;R4represents a hydrogen atom, a C1-C7alkyl group or a halogen atom;R5represents hydrogen atom, a halogen atom or a C1-C7alkyl group; andR6represents a hydrogen atom, a C1-C7alkyl group or a C2or C3alkenyl group,under the proviso that R2and R4can only both represent a hydrogen atom if both R1and R5represent a C1-C7alkyl group and R3represents a halogen atom.The composition is particularly useful for the blockage of sodium channels and/or influencing the kinetics of sodium channels and thus can be used as local anesthetic, antidysrhythmic, anticonvulsant/antiepilepticand spasmolytic.

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