Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-02-01
1998-05-12
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514256, 514315, 514430, 514449, A61K 3150, A61K 31505, A61K 31445, A61K 3138
Patent
active
057505284
ABSTRACT:
Compounds which block neuronal M-channels are useful for treating conditions involving neurotransmitter deficiencies, traumatic brain injury, or the depressive phase of bipolar disorder. Compounds can be evaluated for utility in treating these conditions by determining whether they are capable of blocking neuronal M-channels.
REFERENCES:
patent: 5173489 (1992-12-01), Earl et al.
Lampe and Brown, Electrophysiological Effects of DuP 996 on Hippocampal CA1 Neurons, Soc. Neuroscience Abstr., 17 1588, Abstract #632.19 (1991).
Frey et al., DuP996, a Novel Neurotransmitter Releaser, Blocks Voltage-Activated Potassium Currents in Cultured Neocortical Neurons, Soc. Neuroscience Abstr., 17 1588, Abstract #632.20 (1991).
Aiken and Brown, Linopirdine (DuP 996), A Neurotransmitter Release Enhancer, Blocks M-Current in Rat CA1 Hippocampal Neurons, Biophy.J. 66:A210 (1994) Tu-Pos 410 and Brain Research Assoc. Abstracts 11:67, Abstract #17.200 (1994).
Maciag, et al., Studies on the Role of K+, Cl-, and Na+ Ion Permeabilities in the Acetylcholine Release Enhancing Effects of Linopirdine (DuP 996) in Rat Cerebral Cortical Slices, J. Pharmacol. Exper. Therapy, 271, 891-897 (1994).
Aiken, et al., Reduction of Spike Fequency Adaptation and Blockade of M-Current in Rat CA1 Pyramidal Neurones by Linopirdine (DuP 996), a Neurotransmitter Release Enhancer, Br.J.Pharmacol.115, 1163-1168 (1995).
Aiken Simon Piers
Brown Barry Stephen
Earl Richard Alan
Hartig Paul Richard
Teleha Christopher Allan
Fay Zohreh
The DuPont Merck Pharmaceutical Company
LandOfFree
Blockade of neuronal m-channels as a therapeutic approach to the does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Blockade of neuronal m-channels as a therapeutic approach to the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Blockade of neuronal m-channels as a therapeutic approach to the will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-979210