Block copolymer matrix for transdermal drug release

Details Block copolymer matrix for transdermal drug release Block copolymer matrix for transdermal drug release

1988-04-22

1989-06-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 424484, 424486, A61F 1302

Patent

active

048407968

ABSTRACT:
A transdermal drug delivery system, is provided which includes, in combination, an impermeable backing member, a matrix containing a medicinally active ingredient, and a pressure sensitive adhesive for affixing the system to the skin of a patient; the improvement in such system is based on the fact that said matrix is drug permeable (including to hydrophilic drugs) and is formed of a copolymer which can be softened sufficiently at temperature between 45.degree. C. and 160.degree. C. to incorporate the drugs therein without damage caused by heat or chemical reactions, the matrix being formed of a substantially linear block copolymer which is a reaction product of a polydiorganosiloxane which forms "soft" segments in said reaction product and a diisocyanate which forms "hard" segments, said copolymer having a glass transition temperature between 45.degree. C. and 160.degree. C. said soft segments comprising from 80 to 99 percent by weight, based on the weight of said copolymer, the average molecular weight of the copolymer being between 15,000 and 500,000.

REFERENCES:
patent: 3598122 (1971-08-01), Zaffaroni
patent: 4435180 (1984-03-01), Leeper
patent: 4559054 (1985-12-01), Bruck
patent: 4615699 (1986-10-01), Gale
patent: 4638043 (1987-01-01), Szycher et al.
patent: 4690683 (1987-09-01), Chien et al.

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