Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-06-13
1976-01-13
Gotts, Lewis
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424177, C07C10352, A61K 3700
Patent
active
039323749
ABSTRACT:
A process for preparing bleomycinic acid having a melting point of 228.degree.-230.degree.C. (decomposition) and an analysis of C : 40.80%, H : 5.29%, N : 16.45%, O : 24.78%, S : 4.53%, Cl : 3.37%, and Cu : 4.78% which is characterized by being soluble in water, difficultly soluble in methanol, acetic acid and dimethylsulfoxide, and insoluble in ethanol, ethyl acetate, acetone and ether, and which tests positive to Pauly and Ehrlich reactions but tests negative to ninhydrin, Sakaguchi, Dragendorf, Tollens, ferric chloride, Fehling and Molish reactions, and which has a maximum ultraviolet absorption spectrum at 246 m.mu. and 292 m.mu. and which has an infrared absorption spectrum bands at 3350, 1720, 1670, 1640, 1580, 1460, 1365, 1050, 770 (cm.sup.-.sup.1), and which can be hydrolyzed to yield 2'-(2-aminoethyl)-2,4'-bithiazole-4-carboxylic acid, L-threonine, 4-amino-3-hydroxy-2-methyl-.eta.-valeric acid, .beta.-hydroxy-histidine, .beta.-amino-.beta.-(4-amino-6-carboxy-5-methylpyrimidine-2-yl)-propionic acid, L-.beta.-amino-alanine, L-gulose and 3-0-carbamoyl-D-mannose, which comprises hydrolyzing bleomycin in the presence of a mycelium mass or enzyme.
REFERENCES:
patent: 3846400 (1974-05-01), Umerzawa et al.
Umezawa et al.: J. of Antibiotics, 19A, 200-209 (1966).
Umezawa et al.: J. of Antibiotics, 19A, 210-215 (1966).
Takita et al.: J. of Antibiotics, 21, 79-80 (1968).
Takita et al.: J. of Antibiotics, 22, 237-239 (1969).
Fujii Akio
Shirai Tadashi
Takahashi Yasushi
Umezawa Hamao
Gotts Lewis
Suyat Reginald J.
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
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