Bleomycin gene cluster components and their uses

Details Bleomycin gene cluster components and their uses Bleomycin gene cluster components and their uses

2005-08-09

2005-08-09

Kerr, Kathleen (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C536S023700, C435S320100, C435S252300, C435S254110, C435S419000, C435S325000, C435S252350

Reexamination Certificate

active

06927286

ABSTRACT:
This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of bleomycin inStreptomyces verticillus. The bleomycin gene cluster provides the first hybrid polyketide synthase
onribosomal peptide synthetase pathway and elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for bleomycins, bleomycin analogs, and various other polyketides.

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