Bleomycin conjugates and method

Details Bleomycin conjugates and method Bleomycin conjugates and method

1985-03-15

1988-07-19

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424131, 424DIG6, 514 18, 514 53, 530318, A61K 4300, A61K 3702, A61K 3324, C07K 700

Patent

active

047584211

ABSTRACT:
A bleomycin conjugate for use in targeting a compound to a body tumor. The conjugate includes an oxidized bleomycin/cobalt(III) complex and the compound to be targeted joined to the complex through a monodentate cobalt/sulfur coordinate bond. Also disclosed are methods for preparing the conjugate, and for targeting the compound to a body tumor, for purposes of tumor radioimaging or therapy.

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Strand, S-E., et al., Radioimmunoimaging and Radioimmunotherapy (1983), pp. 307-322, Elsevier.

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