Bleach stable enzymes

Details Bleach stable enzymes Bleach stable enzymes

1988-05-27

1992-06-02

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435220, 435221, 25217412, 935 10, 935 14, C12N 956, C12N 1557, C11D 100

Patent

active

051186233

ABSTRACT:
The methods of the invention can be used to identify sites of cleavage of an enzyme in the presence of hypochlorite. It has been found that such cleavage occurs at tryptophan. Chemical modifications or genetic manipulation to change or delete tryptophan can be done to produce a more stable enzyme which retains activity in the presence of hypochlorite. The invention is particularly applicable to alkaline proteases which are useful in detergent compositions.

REFERENCES:
patent: 3623957 (1971-11-01), Feldman
Estell et al. Journal of Biol. Chem. 260(11):6518-21 1985.
Stauffer and Etson, Journal of Biol. Chem. 244(19) 5333-38, 1969.

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