Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing a carotene nucleus
Patent
1993-11-19
1995-06-06
Knode, Marion C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing a carotene nucleus
4352541, 435171, 435911, C12P 2300, C12P 102, C12N 114
Patent
active
054222478
ABSTRACT:
The present invention is directed toward a method for producing beta-carotene using a mated culture of Mucorales fungi. The method includes mutating and selecting negative (minus mating type) and positive (plus mating type) Mucorales fungal microorganisms, culturing the selected negative and positive microorganisms in an effective medium to form a mated culture that produces beta-carotene, and recovering beta-carotene therefrom. The present invention provides mated cultures that overproduce beta-carotene and is also directed to certain negative and positive microorganisms used to overproduce beta-carotene. The present invention also provides beta-carotene formulations produced by the claimed method, and the use of such formulations, for example, to enhance pigmentation, to reduce damage caused by reactive oxygen species or phototoxic molecules, to prevent or treat cancer or cardiovascular disease, to provide a Vitamin A supplement, to enhance lactation, and to increase fertility.
REFERENCES:
patent: 2865814 (1958-12-01), Hesseltine et al.
patent: 2890989 (1959-06-01), Anderson
patent: 2910410 (1959-10-01), Corman
patent: 2959521 (1960-11-01), Zajic
patent: 2959522 (1960-11-01), Zajic
patent: 3001912 (1961-09-01), Miescher
patent: 3095357 (1963-06-01), Fulde
patent: 3128236 (1964-04-01), Zajic
patent: 3226302 (1965-12-01), Ciegler
patent: 3235467 (1966-02-01), Ninet et al.
patent: 3242054 (1966-03-01), Ninet et al.
patent: 3291701 (1966-12-01), Fulde
patent: 3378460 (1968-04-01), Ninet et al.
patent: 3421980 (1969-01-01), Ninet et al.
patent: 3492202 (1970-01-01), Bohinski
patent: 3522146 (1970-07-01), Jager
patent: 4318987 (1982-03-01), Araujo et al.
patent: 5328845 (1994-07-01), Finkelstein et al.
Murillo et al., "Carotene-Superproducing Strains of Phycomyces", Applied and Environmental Microbiology, vol. 36, No. 5, pp. 639-642, 1978.
Salgado et al., "Carotene-Superproducing Mutants of Phycomyces blakesleeanos", Experimental Mycology, vol. 13, pp. 332-336, 1989.
Cruerger et al., "Strain Development", In: Biotechnology: A Textbook of Industrial Microbiology, Pubumis:Sinauer Associates Inc., pp. 9-17, 1984.
Jacobson, G. K. "Mutations", In: Biotechnology, vol. 1, Rehm et al. (eds), Publisher: Verlag Chemie, pp. 297-299, 1981.
L. Ninet, J. Renaut and R. Tissier, Activation of the Biosynthesis of Carotenoids by Blakeslea trispora, Biotechnology and Bioengineering, vol. XI, pp. 1195-1210 (1969).
L. Ninet and J. Renaut, Carotenoids, Microbial Technology, 2nd ed., vol. 1, pp. 529-544 (1979).
H. J. Nelis and A. P. De Leenheer, A Review: Microbial Sources of Carotenoid Pigments Used in Foods and Feeds, Journal of Applied Bacteriology, vol. 70, pp. 182-184 (1991).
Hanson, A., Production of Pigments and Vitamins, Microbial Technology, pp. 222-250 (1977).
Ciegler, et al., Effect of Various Grains on Production of Beta-Carotene by Mated Strains of Blakeslea trispora, Microbial Production of Carotenoids IV, pp. 94-97 (1958).
Nelis et al., "Microbial Sources of Carotenoid Pigments Used in Foods and Feeds", pp. 181-191, 1991, Journal of Applied Bacteriology, vol. 70.
Murillo et al., "Carotene-Superproducing Strains of Phycomyces", pp. 639-642, 1978, Appl. Environ. Microbiol., vol. 36.
Lampila et al., "A Review of Factors Affecting Biosynthesis of Carotenoids by the Order Mucorales", pp. 65-80, 1985, Mycopathologia, vol. 90.
Cerda-Olmedo, "Production of Carotenoids with Fungi", pp. 27-42, 1989, Biotechnology of Vitamins, Pigments, and Growth Factors, (E. Vandamme, ed).
Byng Graham S.
Finkelstein Mark
Huang Chien-Chang
Leach Jeanette
Tsau Bi-Ru
Dadio Susan M.
Knode Marion C.
Universal Foods Corporation
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