Bladder nuclear matrix proteins, polynucleotide sequences encodi

Details Bladder nuclear matrix proteins, polynucleotide sequences encodi Bladder nuclear matrix proteins, polynucleotide sequences encodi

1996-11-01

1999-02-02

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530300, C07K 1400

Patent

active

058665358

ABSTRACT:
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.

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CUPO, "Electrophoretic Analysis Of Nuclear Matrix Proteins And The Potential Clinical Applications", Journal of Chromatography, vol. 569:389-406, (1991).
Gordon et al., "Organizations of Overlying Human Bladder urothelial Cells", Cancer Research, vol. 53(2):4971-4977, (1993).
Konety et al. "Identification of Nuclear Matrix Protein Alterations Associated wit Renal Cell Carcinoma" The Journal of Urology, vol. 159, No. 4, pp. 1359-1363 (Apr. 1998).
Eberharter et al. "Nuclear Matrix of the Lower Eurkaryote Physarum polycephalum and the Mammalian epithelial LLC-PK.sup.1 cell line," European Journal of Biochemistry, vol. 212, No. 2, pp. 573-580 (Mar. 1993).
Getzenberg et "Bladder Cancer-associated Nuclear Matrix Proteins," Cancer Research, vol. 56, No. 7 pp. 1690-1694 (Apr. 1996).
Keesee et al. "Utilization of Nuclear Matrix Proteins for Cancer Diagnosis," Critical Reviews in Eukaryotic Gene Expression, vol. 6, Nos. 2/3, pp. 189-214 (1996).

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