Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1997-02-03
1998-12-29
Knode, Marian C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 691, 435 693, 4351723, 4352351, 4352523, 4353201, 4242041, 424 932, 530350, 5303894, 5303871, 536 2372, 536 2432, 935 65, C12Q 170, C12Q 168, A61K 3912, C07H 2104
Patent
active
058539808
ABSTRACT:
The present invention relates to the discovery and isolation of a novel hantavirus designated the Black Creek Canal hantavirus. In particular, the present invention relates to nucleic acids of the newly discovered virus and to nucleic acid reagents (primers and probes), purified polypeptides and antibodies for use in methods of detection and prevention of infection by the virus. A vaccine or purified immunogenic polypeptide of the Black Creek Canal hantavirus in a pharmaceutically acceptable carrier is provided. A vector comprising the nucleic acids of the invention is provided. A method of detecting the presence of a hantavirus in a subject comprising contacting an antibody-containing sample from the subject with a purified polypeptide of the invention and detecting the reaction of the polypeptide and the antibody is provided. A method of detecting the presence of the Black Creek Canal hantavirus is provided comprising reverse transcribing viral RNA to synthesize a complementary DNA sequence followed by amplifying the DNA using primers which are selective for the Black Creek Canal hantavirus and detecting the presence of amplification, thereby indicating presence of the Black Creek Canal hantavirus in the sample.
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Elliott Luanne
Ksiazek Thomas G.
Morzunov Sergey
Nichol Stuart T.
Ravkov Eugeny
Knode Marian C.
Lee Datquan
National Institutes of Health Office of Technology Transfer
The United States of America as represented by the Department of
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