Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-06-14
2011-06-14
Ward, Paul V. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S450000, C540S480000
Reexamination Certificate
active
07960372
ABSTRACT:
The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
REFERENCES:
patent: 4415496 (1983-11-01), Harris
patent: 2008/0020986 (2008-01-01), Condon
patent: 2008/0021066 (2008-01-01), Condon
patent: 0 629 627 (1994-12-01), None
patent: 01/85196 (2001-11-01), None
Wolff, M.E., “Burger's Medicinal Chemistry”, 5th Ed., Part 1, pp. 975-977 (1995).
Banker et al., “Modern Pharmaceuticals”, 3rd Ed., p. 596 (1996).
AU Application No. 2007248473 Search Report dated Oct. 29, 2009.
EP Search Report dated Apr. 29, 2010, EP Patent Application No. 07794581.4.
Roy, S., et al., “Exploring Relationships Between Mimic Configuration, Peptide Conformation and Biological Activity in Indolizidin-2-One Amino Acid Analogs of Gramicidin S” Journal of Peptide Research, Blackwell Publishing Ltd., Oxford: GB, vol. 60, No. 4, Oct. 1, 2002, pp. 198-214.
Wisskirchen, F.M.., et al., “Conformational Restraints Revealing Bioactive Beta-Bend Structures for Halpha CGRP8-37 at the CGRP2 Receptor of the Rat Prostatic Vas Deferens,” British Journal of Pharmacology, vol. 126, No. 5, Mar. 1999, pp. 1163-1170.
Peng, Y., et al., “Design and Synthesis of a 1,5-diazabicyclo[6,3,0] dodecane amino acid derivative as a novel dipeptide reverse-turn mimetic,” Tetrahedron Letters, Elsevier, Jul. 3, 2006, pp. 4769-4770.
Sun, H., et al., “Structure-Based Design of Potent, Conformationally Constrained SMAC Mimetics,” Journal of the American Chemical Society, Jan. 1, 2004, pp. 16686-16687.
Sun, et al., “Supporting Information: Design of Potent, Conformationally Constrained SMAC Mimetics,” Journal of American Society, vol. 126, No. 51, Dec. 29, 2004, pp. S1-S20.
Sun, Haiying, et al., “Structure-based Design, Synthesis, and Evaluation of Conformationally Constrained Mimetics of the Second Mitochondria-Derived Activator of Caspase that Target the X-Linked Inhibitor of Apoptosis Protein/Caspase-9 Interaction Site,” Journal of Medicinal Chemistry, American Chemical Society, vol. 47, No. 17, Aug. 12, 2004, pp. 4147-4150.
Bach,A.C., “Synthesis and NMR Conformational Analysis of a B-Turn Mimic Incorporated Into Gramicidin S” International Journal of Peptide and Protein Research, vol. 38, No. 4, Oct. 1, 1991, pp. 314-323.
Sun, H., et al., “Design and Synthesis of a Potent Biotinylated SMAC Mimetic,” Tetrahedron Letters, vol. 46, No. 41, Oct. 10, 2005, pp. 7015-7018.
Nagai, U., et al., “Bicyclic Turned Dipeptide (BTD) as a Beta-Turn Mimetic: Its Design Synthesis and Incorporation into Bioactive Peptides,” Tetrahedron, vol. 49, No. 17, Apr. 23, 1993, pp. 3577-3592.
Lombart, H., et al., “Rigid Dipeptide Mimetics: Efficient Synthesis of Enantiopure Indolizidinone Amino Acids,” Journal of Organic Chemistry, vol. 61, No. 26, Dec. 27, 1996, pp. 9437-9446.
Examination Report, NZ Patent Application No. 572531, dated Jun. 3, 2010.
Cai Qian
Lu Jianfeng
Nikolovska-Coleska Zaneta
Peng Yuefeng
Qin Dongguang
Casimir Jones SC
The Regents of the University of Michigan
Ward Paul V.
LandOfFree
Bivalent Smac mimetics and the uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bivalent Smac mimetics and the uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bivalent Smac mimetics and the uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2660692