Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-06-16
2000-08-15
Johnson, Nancy A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303882, 5303871, 435326, 435332, 4241411, 4241521, C07K 1618, C07K 1628, C12N 512
Patent
active
061038792
ABSTRACT:
Antibodies and Bivalent molecules which activate erythropoietins and induce the proliferation or differentiation of erythroid progenitor cells are provided. Also provided are methods of using such bivalent molecules for drug discovery, diagnosis and treatment of disorders related to the activation of an erythropoietin receptor.
REFERENCES:
Waldmann, Science 252:1657, 1991.
S. Elliott Et Al.: "Isolation and Characterization of RhuEPO Receptor Monoclonal Antibodies That Activate The EPO Receptor." Experimental Hematology, vol. 23, No. 8: p. 828, XP002044302; Aug. 1995, New York, NY, USA.
Hallgeir Rui Et Al.: "JAK2 Activation and Cell Proliferation Induced by Antibody-Mediated Prlocatin Receptor Dimerization," Endocrinology, vol. 135, No. 4: pp. 1299-1306, XP002044303, Oct. 1994, Philadelphia, PA, USA.
H. Schneider Et Al.: "Homodimerization of Erythropoietin Receptor by a Bivalent Monoclonal Antibody Triggers Cell Proliferation and Differentiation of Erythroid Precursors", Blood, vol. 89, No. 2: pp. 473-482, XP002044304, Jan. 1997, New York, NY,USA.
S. Elliott Et Al.: "Activation of the Erythropoietin (EPO) Receptor by Bivalent Anti-EPO Receptor Antibodies", The Journal Biological Chemistry, vol. 271, No. 40: pp. 24691-24697, XP002044305, Oct. 1996, Baltimore, MD, USA.
Chaovapong Warak Lee
Giebel Lutz B.
Karkaria Cyrus
Ross Michael J.
Schneider Helmut H.
AxyS Pharmaceuticals, Inc.
Johnson Nancy A.
Montgomery Wayne W.
LandOfFree
Bivalent molecules that form an activating complex with an eryth does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Bivalent molecules that form an activating complex with an eryth, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bivalent molecules that form an activating complex with an eryth will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2008202