Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai
Patent
1991-05-07
1993-01-19
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Silicon containing doai
5142245, 5142322, 514253, 514316, 514455, 544 55, 544 78, 544 82, 544229, 544316, 544357, 544375, 544378, 546 14, 546186, 546187, 548406, 548518, 549214, 549387, A61K 31445
Patent
active
051807173
ABSTRACT:
Bivalent ligand compounds synthesized from a tether composition joining two heterocyclic groups comprising furochromones, furobenzoxazinones, and benzobisdifurans. These compounds show pharmacological activity in blocking ACAT enzymes which are major regulators of cholesterol metabolism. The compounds also show activity in lowering plasma triglycerides and elevating HDL cholesterol. They are useful in the prevention or treatment of the constriction or obstruction of arterial vessels, atherosclerosis, hyperlipidemia, hypertriglyceridemia, chylomicronemia, and pancreatitis.
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Bell Frank P.
Gammill Ronald B.
Corneglio Donald L.
Daus Donald G.
The Upjohn Company
Wootton Thomas A.
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