Bivalent ligands effective for blocking ACAT enzyme for lowering

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Silicon containing doai

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5142245, 5142322, 514253, 514316, 514455, 544 55, 544 78, 544 82, 544229, 544316, 544357, 544375, 544378, 546 14, 546186, 546187, 548406, 548518, 549214, 549387, A61K 31445

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051807173

ABSTRACT:
Bivalent ligand compounds synthesized from a tether composition joining two heterocyclic groups comprising furochromones, furobenzoxazinones, and benzobisdifurans. These compounds show pharmacological activity in blocking ACAT enzymes which are major regulators of cholesterol metabolism. The compounds also show activity in lowering plasma triglycerides and elevating HDL cholesterol. They are useful in the prevention or treatment of the constriction or obstruction of arterial vessels, atherosclerosis, hyperlipidemia, hypertriglyceridemia, chylomicronemia, and pancreatitis.

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