Biurethane derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S328000, C514S352000, C514S357000, C514S376000, C514S424000, C514S425000, C514S590000, C540S526000, C544S166000, C544S239000, C544S383000, C546S220000, C546S221000, C546S325000, C548S229000, C548S543000, C548S545000, C564S035000

Reexamination Certificate

active

06943179

ABSTRACT:
Novel compounds of the formula I in which X, Y, Z, R, R1, R2and R3are as defined in Patent Claim1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of tromboembolic diseases and for the treatment of tumors

REFERENCES:
patent: 5849732 (1998-12-01), Suzuki et al.
patent: 0790240 (1997-08-01), None
Zinner, G. et al: “Carbamoylation of hydrazine derivatives” Archiv der Pharmazie (Weinheim, Germany) 1973, 306(1), 35-44, 1973.
Khau, View V. et al “1,3-Dipolar cycloreversion fo a 1, 3, 4-oxadiazoline as a controlled azomethine imine surrogate for pyrazolidine synthesis” Tetrahedron Letter 1996, 37(25), 4323-4326.
Database CA 'online! Chemical Abstracts Service, Columbis, Ohio, US: Utsumi, Naoshi et al : “Production of foamy material” retreived from STN Database accession No. 80:71652 CA.
Cain B F et al : “Potential Antityumour Agents. X. Bisquaternary Salts” Journal of Medicinal Chemistry, Amercian Chemical Society. Washington, US. Bd. 12, Nr.2, Mar. 1969, Seiten 199-206.

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