Bitterness-reduced intrabuccally quick disintegrating...

Details Bitterness-reduced intrabuccally quick disintegrating... Bitterness-reduced intrabuccally quick disintegrating...

2006-02-14

2006-02-14

Page, Thurman K. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S400000, C424S464000, C424S474000, C424S489000, C424S490000

Reexamination Certificate

active

06998139

ABSTRACT:
The invention relates to a method for reducing bitterness of bitter drugs, which does not cause delay of release rate, does not show reduction of bioavailability in comparison with conventional pharmaceutical preparations and, due to the use of additives generally used in the field of pharmaceutical preparation, has high practical value, and to intrabuccally quick disintegrating tablets having reduced bitterness of bitter drugs. Illustratively, it relates to an intrabuccally quick disintegrating tablet which comprises a bitter drug and a water-insoluble substance having an average particle size of 30 μm or less, wherein the water-insoluble substance disperses as particles on the tongue surface prior to the release of the bitter drug.

REFERENCES:
patent: 5576014 (1996-11-01), Mizumoto et al.
patent: 5785984 (1998-07-01), Kurihara et al.
patent: 6248357 (2001-06-01), Ohno et al.
patent: 6287596 (2001-09-01), Murakami et al.
patent: 2002/0094345 (2002-07-01), Abelaira et al.
patent: 0 745 382 (1996-12-01), None
patent: 1 072 256 (2001-01-01), None
patent: 8-9897 (1996-01-01), None
patent: WO 99/47124 (1999-09-01), None

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