Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-12-21
2000-07-11
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546332, A61K 3144, C07D21356
Patent
active
060873833
ABSTRACT:
The present invention provides the crystalline bisulfate salt of the formula ##STR1## which is found to have unexpectedly high solubility/dissolution rate and oral bioavailability relative to the free base form of this azapeptide HIV protease inhibitor compound.
REFERENCES:
patent: 5849911 (1999-12-01), Fassler et al.
Lindrud Mark D.
Pudipeddi Madhusudhan
Singh Janak
Bristol--Myers Squibb Company
Dentz Bernard
Morse David M.
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