Organic compounds -- part of the class 532-570 series – Organic compounds – Diazoamino
Patent
1994-09-12
1998-09-15
Higel, Floyd D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Diazoamino
514150, 514151, 534550, 534552, 534553, 534554, C07C24500, A61K 31655
Patent
active
058080384
ABSTRACT:
The present invention is directed to bistriazene compounds, pharmaceutical compositions containing effective anti-cancer amounts of these compounds, a method for treating cancer comprising administering to affected subjects an anti-cancer effective amount of a bistriazene compound, and the use of bistriazene compounds as crosslinking reagents applicable to the synthesis and manipulation of polymeric macromolecules.
REFERENCES:
patent: 2769819 (1956-11-01), Sommers et al.
patent: 3187020 (1965-06-01), Minisci et al.
patent: 3947247 (1976-03-01), Kohrman et al.
Vaughan et al., Jour. of Medic. Chem. (1984) 27(3):357-403.
Pochinok et al., Chemical Abstracts (1977) 86(25), #188927k.
Vilenskii et al., Chemical Abstracts, (1967) 67(5), #27572h.
John McMurry, Organic Chemistry 2ed., pp. 738-741, 1117-1118 (1988).
John H. Fletcher, et al., Nomenclature of Organic Compounds, p. 167, p. 314 (1974).
G. Zubay, Biochemistry, pp. 664-667 (1983).
B.G. Katzung, ed., Basic and Clinical Pharmacology, pp. 668-671 (1987).
P.A.S. Smith, Derivatives of Hydrazine and Other Hydronitrogens Having N--N Bonds, pp. 289-292 (1983).
Clarke et al (1955) Proc. Soc. Exp. Biol. Med. 90:484-88.
R.L. Comis, (1976) Cancer Treatment Reports 60:165-176.
Fiebig et al., (1987) European Journal of Cancer and Clinical Oncology 23:937-948.
Fiebig et al. (1989) Strahlenther. Onkol. 165:522-524.
B.T. Hill, (1987) Cancer Treatment Reviews 14:197-202.
Scalabrino et al. (1981) in Klein et al., eds., Advances in Cancer Research vol. 35, Academic Press, New York, pp. 151-267.
Scalabrino et al., (1982) in Klein et al., eds., Advances in Cancer Research vol. 36, Academic Press, New York, pp. 1-103.
A.E. Pegg, (1988) Cancer Research 48:759-774.
Randall et al. (1984) Journal Chem. Society Perkin Trans. II:251-253.
Schmiedekamp et al., (1988) Journal of Organic Chemistry 53:3433-3436.
Sieh et al. (1981) Journal of the American Chemical Society 103:442-445.
Smith et al., (1984) Journal of the American Chemical Society 106:1056-1059.
Smith et al., (1986) Journal of the American Chemical Society 108:3726-3730.
Smith et al (1988) The Journal of Organic Chemistry 53:1467-1471.
Smith et al., (1986) The Journal of Organic Chemistry 51:3751-3757.
Smith et al. (1989) The Journal of Organic Chemistry 54:1036-1042.
Vaughan et al., (1984) Journal of Medicinal Chemistry 27:357-363.
J.D. Watson (1987) Molecular Biology of the Gene, The Benjamin Cummings Publishing Company, Inc., Menlo Park, California pp. 346-347.
English translation of Pochinok et al., Ukrain Khim. Zhur., 25, 774-780 (1959) "Aliphatic and Aliphatic-Aromatic Bis-Triazenes".
Pochinok et al I, Chemical Abstracts, vol. 54, No. 13034i (1960).
Pochinok et al II, Chemical Abstracts, vol. 86, No. 188927k (1977).
Pochinok et al III, Chemical Abstracts, vol. 102, No. 61876m (1985).
Vilenskii et al, Chemical Abstracts, vol. 67, No. 27572h (1967).
Manning et al, Can. J. Chem., 62(4), pp. 749-754 (1984).
Blumenstein Jeffrey J.
Michejda Christopher J.
Higel Floyd D.
The United States of America as represented by the Secretary of
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