Bispidine derivatives, their preparation, and drugs containing s

Details Bispidine derivatives, their preparation, and drugs containing s Bispidine derivatives, their preparation, and drugs containing s

1978-06-13

1980-01-15

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546122, 546123, A61K 31445, C07D47108

Patent

active

041839358

ABSTRACT:
Bispidine derivatives of the formula ##STR1## where R.sup.1 is H or C.sub.6 H.sub.5, R.sup.2 is H, Cl or CF.sub.3, R.sup.3 is H, F or Cl and X is 0 or 1, and drugs which contain these compounds. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzylpiperid-4-one with appropriately substituted phenylalkylamines, followed by reduction. They exhibit mainly anti-arrhythmic action.

REFERENCES:
patent: 3962449 (1976-06-01), Binnig et al.
Ruenitz, et al., J. of Med. Chem., 20, (1977), pp. 1668-1671.

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