Bispidine derivatives as class III antiarrhythmic agents

Details Bispidine derivatives as class III antiarrhythmic agents Bispidine derivatives as class III antiarrhythmic agents

1988-09-22

1990-09-25

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546122, C07D47102

Patent

active

049593730

ABSTRACT:
Bispidine derivatives of the formula I ##STR1## where R, R.sup.1 and R.sup.3 are identical or different and are each H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy, when Y is ##STR2## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN, C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.4 R.sup.5 where R.sup.4 and R.sup.5 are each C.sub.1 -C.sub.4 -alkyl, when Y is ##STR3## R.sup.2 is C.sub.1 -C.sub.4 -alkyl, halogen, --CN.sub.1 C.sub.1 -C.sub.4 -alkoxy, --NHSO.sub.2 CH.sub.3, --CF.sub.3, NH-acetyl or --NR.sup.9 R.sup.10 where R.sup.9 is C.sub.1 -C.sub.4 -alkyl and R.sup.10 is H or C.sub.1 -C.sub.4 -alkyl, and when X is not CH.sub.2 R.sub.2 may also be NO.sub.2 or NH.sub.2, X is --CH.sub.2 --, --C(O)-- or --C(R.sup.6)OR.sup.7 -- (where R.sup.6 is H or C.sub.1 -C.sub.4 -alkyl and R.sup.7 is H, C.sub.1 -C.sub.4 -alkyl or ##STR4## where R.sup.8 is H, C.sub.1 -C.sub.4 -alkyl, halogen or C.sub.1 -C.sub.4 -alkoxy), Y is --C(O) or --CONH-- and Z is C.sub.1 -C.sub.4 -alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

REFERENCES:
patent: 4459301 (1984-07-01), Binnig et al.
Ruenitz et al., Antiarrhythmic Activity of Some N-Alkylbispidinebenzamides, 1979, vol. 22, No. 9, J. M. Chem.
Galvez et al., Struct. and Conform. Study of Diazabicyclanones & Diazabicyclanols, J. Mol. Struct., 1985, 127(3-4).
Gubasheva et al., deposited doc., 1982, 3359-82, 12 pp. Synthesis and Stereochemistry of Heteroanalogs. . .

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