Bisphosphonic acid derivatives, as bone resorption inhibitors

Details Bisphosphonic acid derivatives, as bone resorption inhibitors Bisphosphonic acid derivatives, as bone resorption inhibitors

1992-02-06

1994-09-27

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 91, 514278, 546 16, 546 32, 548407, 548513, 548514, C07F 959, A61K 31675

Patent

active

053507436

ABSTRACT:
A bisphosphonic acid derivative of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A is ##STR2## each of R.sup.3 and R.sup.4, which may be the same or different, is (i) a hydrogen atom, (ii) a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group, a C.sub.1-6 alkyl-carbonyl group, a C.sub.2-6 alkenyl-carbonyl group, a C.sub.2-6 alkynyl-carbonyl group R.sup.5 and R.sup.6, which may be the same or different, is a hydrogen atom, a hydroxyl group, a halogen atom, a cyano group, a carbamoyl group, an aralkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted amino group, a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group;

REFERENCES:
patent: 3846420 (1974-11-01), Wollmann et al.
patent: 3899496 (1975-08-01), Schindler et al.
Chemical Abstracts, vol. 89(23) Abst. No. 197,715d, Dec. 04, 1978.
Chemical Abstracts, vol. 92(17) Abst. No. 146,905v, Apr. 28, 1980.

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