Bisphosphonic acid derivatives, and pharmaceutical use

Details Bisphosphonic acid derivatives, and pharmaceutical use Bisphosphonic acid derivatives, and pharmaceutical use

1994-09-09

1996-04-30

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514103, 558158, 546 24, 548112, 548118, C07F 938, C07F 940, A61K 3166

Patent

active

055125522

ABSTRACT:
A bisphosphonic acid derivative of the general formula (I): ##STR1## wherein A is an optionally substituted cyclic group; R.sup.1 is hydrogen atom or a lower alkanoyl group; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and are hydrogen atom or a lower alkyl group; m is 0, 1 or 2; and n is an integer from 2 to 10, or a salt thereof is disclosed. A process for its production and a bone resorption inhibitor containing the compound of the general formula (I) or a salt thereof are also disclosed.

REFERENCES:
patent: 4096208 (1978-06-01), Dursch et al.
patent: 4719203 (1988-01-01), Bosies et al.
patent: 4746654 (1988-05-01), Breliere et al.
patent: 5036058 (1991-07-01), Jaeggi et al.

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