Bisphosphonates, processes for preparation and pharmaceutical co

Details Bisphosphonates, processes for preparation and pharmaceutical co Bisphosphonates, processes for preparation and pharmaceutical co

1993-03-08

1994-08-16

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558158, 558161, 562 20, A61K 3166, C07F 940, C07F 938

Patent

active

053387317

ABSTRACT:
Bisphosphonate compounds are of the Formula (I): ##STR1## wherein Y is .dbd.O or .dbd.N--OH and n is from 3 to 24, and further wherein when Y is .dbd.O, (i) R.sub.1 is hydrogen and R.sub.2 is sodium, or (ii) R.sub.1 is sodium and R.sub.2 is methyl, and when Y is .dbd.N--OH, R.sub.1 is sodium and R.sub.2 is methyl.

REFERENCES:
patent: 3012054 (1961-12-01), Moss
patent: 4060546 (1977-11-01), Blaser et al.
Kanaan et al, Phosphorous and Sulfur, 1988, vol. 37, pp. 217-229.
Hilderbrand, CRC, "The Role of Phosphonates in Living Systems", pp. 55-96 1980.
Hilderbrand, CRC, "The Role of Phosphonates in Living Systems", pp. 161-188 1980.
Rafik Karaman et al, Acylphosphonic Acids and Methyl Hydrogen Acylphosphonates: Physical and Chemical Properties and Theoretical Calculations, J. Chem. Soc. 1989.
Chem. Abstr. 1988, 110(2), 13646e.
Chem. Abstr. 1988, 109(7), 54960a; BE 1000075A1, Feb. 02, 1988.
The Merck Index; Eleventh Edition; Merck: Rahway, NJ, 1989; No. 1512.
Gallez, B. et al, Appl. Radiat. Isot. 1988, 39(9), 1011-14.

Affiliated with

Also associated with

Rating

Bisphosphonates, processes for preparation and pharmaceutical co does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bisphosphonates, processes for preparation and pharmaceutical co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bisphosphonates, processes for preparation and pharmaceutical co will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-951941