Bisphosphonate derivative

Details Bisphosphonate derivative Bisphosphonate derivative

1992-12-24

1995-06-27

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552507, 540 5, 549220, 562 21, 558161, C07J 100

Patent

active

054281814

ABSTRACT:
A compound represented by the general formula: ##STR1## wherein A-O-denotes a residue of a compound having an estrogenic activity; R.sub.1 denotes H or a C.sub.1 -C.sub.6 alkyl group; X denotes a single bond, a C.sub.1 -C.sub.10 alkylene group or a group of the formula ##STR2## wherein R.sub.2 denotes H or a C.sub.1 -C.sub.5 alkyl group; Z denotes a nitro group or a halogen; n is an integer of 3 to 12; k is an integer of 1 to 5; L is an integer of 0 to 5; and q is an integer of 1 to 3,

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J. Kulagowski et al.; "Inhibitors of myo-Inositol Monophosphatase Containing Methylenebisphosphonic Acid as a Replacement for a Phosphate Group", J. Chem. Coc. Chem Commun.; pp. 1649-1651 (1991).
D. Pert et al.; "An alternative Route to 2-Bromo-and 2-Iodo-estradiols from Estradiol"; Aust. J. Chem.; 40:303-309 (1986).
H. Fleisch, "Bisphosphonates-History and Experimental Basis"; Pergamon Journals Ltd.; pp. S23-S26 (1987).
M. Regitz et al.; "Syntheses von Alpha-Diazo-Phosphonsaureestern", Chem. Ber.; 101:3374-3734 (1968).
J. Walmsley et al.; "The Donor Properties of Bis-(diisopropoxyphosphinyl)-methane and Bis-(di-N-butylphosphinyl)-methane"; Inorganic Chemistry; pp. 312-318 (1962).
Fujisaki et al., Chemical Abstracts, vol. 114, No. 9, p. 766; column 2, abstract No. 82119 (Mar. 4, 1991).
Fujisaki et al., Chemical Abstracts, vol. 115, No. 5, p. 877; column 2, abstract No. 49974 (Aug. 5, 1991).

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