Bisphosphonate coated implant device and method therefor

Details Bisphosphonate coated implant device and method therefor Bisphosphonate coated implant device and method therefor

2007-01-16

2007-01-16

Witherspoon, Sikarl A. (Department: 1621)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C427S002140, C623S011110

Reexamination Certificate

active

10534666

ABSTRACT:
The method of the present invention is for coating an implant device. The implant device is coated with a protein film, such as fibrinogen. A first bisphosphonate substance, such as pamidronate, is immobilized to the protein film. A second bisphosphonate substance, such ibandronate, is adsorbed to the first bisphosphonate wherein the first bisphosphonate is different from the second bisphosphonate.

REFERENCES:
Yoshinari et al. Immobilization of bisphosphonates on surface modified titanium. Biomaterials, 2001, vol. 22, p. 709-715.
Kajiwara et al. The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats. Biomaterials, 2005, vol. 26, p. 581-587.
Tengvali et al. Surface immobilized bisphosphonate improves stainless-steel screw fixation in rats. Biomaterials, 2004, vol. 25, p. 2133-2138.

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