Bispecific reagents for AIDS therapy

Details Bispecific reagents for AIDS therapy Bispecific reagents for AIDS therapy

1994-05-16

1999-04-27

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

4241431, 4241481, 5303873, 53038822, 53038835, C07K 1610, C07K 1628, A61K 39395, A61K 3921

Patent

active

058978615

ABSTRACT:
Bispecific molecules which react both with the high-affinity Fc.gamma. receptor (Fc.gamma.RI) of effector cells and with the human immunodeficiency virus (HIV), or component thereof are disclosed. Binding of these bispecific molecules to the Fc.gamma.RI is not blocked by the binding of the Fc region of IgG to that same receptor, as the bispecific molecules are specific for an epitope on the Fc.gamma.RI distinct from the Fc binding epitope. The bispecific molecules are useful for targeting human effector cells to a target on HIV. Also disclosed are methods of treating HIV infection using these bispecific molecules.

REFERENCES:
patent: 4444878 (1984-04-01), Paulus
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4676980 (1987-06-01), Segal et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4954617 (1990-09-01), Fanger et al.
patent: 5013548 (1991-05-01), Haynes et al.
patent: 5104790 (1992-04-01), Flesher et al.
patent: 5166050 (1992-11-01), Shriver et al.
patent: 5169939 (1992-12-01), Gefter et al.
patent: 5180660 (1993-01-01), Ohno
patent: 5217895 (1993-06-01), Ohno
patent: 5219728 (1993-06-01), Khayat et al.
patent: 5292668 (1994-03-01), Paulus
Zarling, J. M. et al., J. Immunol. 140:2609-2613, Lysis of cells infected with HIV-1 by human lyphocytes targeted with monoclonal antibody heteroconjugates, Apr. 15, 1988.
Anasetti, C. et al., J. Immunol. 139:1772-1779, Induction of alcium flux and enhancement of cytolytic activity by natural killer cells by cross-linking of the sheep erythrocyte binding proteins (CD2) and the Fc-receptor (CD16), Sep. 15, 1987.
Fleit, H. B. et al., PNAS 79:3275-3279, Human neutrophil Fc-gamma receptor distribution and structure, May 1982.
Paul, W.F., Fundamental Immunology (1993), pp. 308-309, Raven Press, N.Y.
Traunecker, A. et al. (1989) "High efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules" Nature 339:68-70.
International Search Report for EP 96 20 1024.5 issued Aug. 13, 1996.
Anderson et al. (1986) J. Biol. Chem. 261:12856 (preprint enclosed).
Shen et al. (1986) J. Immunol. 137:3378-3382.
Karpovsky et al. (1984) J. Exp. Med. 160:1686-1701.
Till et al. (1988) Science 242:1166-1168.
Chaudhary et al. (1988) Nature 335:369-372.
Capon et al. (1989) Nature 337:525-530.
Clark et al. (1990) in Bispecific Antibodies and Targeted Cellular Cytotoxicity, Second International Conference, Seillac, France, pp. 243-247.
de Leij et al. (1990) in Bispecific Antibodies and Targeted Cellular Cytotoxicity, Second International Conference, Seillac, France, pp. 249-253.
Nitta et al. (Feb. 17, 1990) The Lancet, pp. 368-371.
Ball et al. (1992) J. Hematotherapy (in press) pp. 85-94.
Connor et al. (Nov. 1991) Proc. Natl. Acad. Sci USA, Vo. 88, pp. 9593-9597.
Mabondzo et al. (1992) The Journal of Infectious Diseases 166:93-9.
W. F. Paul, Fundamental Immunology, 3rd edition (1993), Raven Press, New York. pp. 1375-1397.
Takeda, A. et al., J. Clin. Invest. 89:1952-1957 (1992), "distinction of human immunodeficiency virus type 1 neutralization and infection enhancement by human monoclonal antibodies to glycoprotein 120".

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