Bispecific monoclonal antibody, its production and use

Details Bispecific monoclonal antibody, its production and use Bispecific monoclonal antibody, its production and use

1989-12-27

1992-08-25

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303889, 53038822, 5303888, 5303917, 514 2, 435972, 435 71, 43524026, 435 7021, 4351722, 43524027, 424 858, 424 8591, A61K 3900, A61K 3514, C12Q 100, G01N 3353

Patent

active

051417367

ABSTRACT:
The present invention discloses, a bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, which can carry an anasamitocin derivative in a stable and inactive form at other sites than the target and release the active-form ansamitocin derivative at the target site, so that an anticancer agent having excellent durability and selectivity with little adverse action can be prepared using the bispecific monoclonal antibody and ansamitocin derivatives.

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patent: 4962188 (1990-10-01), Frankel
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Pirker et al et al (1985) Anti Transferrin Receptor Antibody-Cancer Res 45:751-757.
Wong et al (1987) Bispecific Monoclonal Antibody--J Immunol 139:1369-1475.
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Corvalan et al (1987) Construction & Charact.--Cancer Immunol Immunother 24: 127-132.
Iwasa, et al., The Physio-Chemical Biology, vol. 32, No. 5, p. 225(1988).

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